Document Detail


Lichenoid tissue reaction (LTR) induced by local transfer of Ia-reactive T-cell clones. II. LTR by epidermal invasion of cytotoxic lymphokine-producing autoreactive T cells.
MedLine Citation:
PMID:  2439608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have suggested that T lymphocytes with helper phenotype may play an important role in the pathogenesis of lichenoid tissue reactions (LTR). In order to elucidate whether murine self-Ia-specific autoreactive T cells with helper phenotype can induce LTR in naive syngeneic hosts, two clones of autoreactive cloned T cells with both helper and cytotoxic activities, capable of producing the cytotoxic lymphokines gamma interferon and lymphotoxin in response to self-Ia antigens, were examined for their ability to induce LTR. One clone, BB5, when injected into footpads of syngeneic hosts, induced prominent epidermotropic cellular infiltrates that led to basal vacuolar degeneration and Civatte body formation; the other clone, C10, did not. No difference between BB5 and C10 was detected with respect to their ability to induce delayed-type hypersensitivity reactions. Immunohistochemical studies using anti-Lyt monoclonal antibodies showed that BB5-induced LTR was induced by the epidermal invasion of the injected BB5 cells themselves. We further observed that the infusion of BB5 cells not only resulted in Ia antigen expression on keratinocytes, but was also accompanied by a morphologic change in Langerhans cells at 24 h, when the epidermal invasion had not yet developed. However, similar observations were also observed with C10 cells, indicating that Ia expression on keratinocytes may not be a prerequisite for the induction of LTR.
Authors:
T Shiohara; N Moriya; T Mochizuki; M Nagashima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  89     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-07-28     Completed Date:  1987-07-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Clone Cells
Epidermis / cytology,  pathology*
Female
Histocompatibility Antigens Class II / immunology*
Histocytochemistry
Hypersensitivity, Delayed / immunology
Immunochemistry
Keratins
Lymphokines / biosynthesis*
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
T-Lymphocytes / immunology,  transplantation*
T-Lymphocytes, Cytotoxic / metabolism*,  pathology
Transplantation, Isogeneic
Grant Support
ID/Acronym/Agency:
25252//PHS HHS; 5P01AM/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens Class II; 0/Lymphokines; 68238-35-7/Keratins

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