Document Detail

Lichenoid tissue reaction (LTR) induced by local transfer of Ia-reactive T-cell clones. II. LTR by epidermal invasion of cytotoxic lymphokine-producing autoreactive T cells.
MedLine Citation:
PMID:  2439608     Owner:  NLM     Status:  MEDLINE    
Recent studies have suggested that T lymphocytes with helper phenotype may play an important role in the pathogenesis of lichenoid tissue reactions (LTR). In order to elucidate whether murine self-Ia-specific autoreactive T cells with helper phenotype can induce LTR in naive syngeneic hosts, two clones of autoreactive cloned T cells with both helper and cytotoxic activities, capable of producing the cytotoxic lymphokines gamma interferon and lymphotoxin in response to self-Ia antigens, were examined for their ability to induce LTR. One clone, BB5, when injected into footpads of syngeneic hosts, induced prominent epidermotropic cellular infiltrates that led to basal vacuolar degeneration and Civatte body formation; the other clone, C10, did not. No difference between BB5 and C10 was detected with respect to their ability to induce delayed-type hypersensitivity reactions. Immunohistochemical studies using anti-Lyt monoclonal antibodies showed that BB5-induced LTR was induced by the epidermal invasion of the injected BB5 cells themselves. We further observed that the infusion of BB5 cells not only resulted in Ia antigen expression on keratinocytes, but was also accompanied by a morphologic change in Langerhans cells at 24 h, when the epidermal invasion had not yet developed. However, similar observations were also observed with C10 cells, indicating that Ia expression on keratinocytes may not be a prerequisite for the induction of LTR.
T Shiohara; N Moriya; T Mochizuki; M Nagashima
Related Documents :
355568 - Analogous functions of macrophages and langerhans cells in the initiation in the immune...
2784718 - A specific defect in the proliferative capacity of b cells from old mice stimulated wit...
1085338 - A new i subregion (i-j) marked by a locus (ia-4) controlling surface determinants on su...
68988 - Properties of reticulum cell sarcomas in sjl/j mice. v. nature of reticulum cell sarcom...
12095148 - Effect of continuous subcutaneous administration of a low dose of g-csf on stem cell mo...
25478178 - Primary mesenchymal stem cells in human transplanted lungs are cd90/cd105 perivascularl...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  89     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-07-28     Completed Date:  1987-07-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Clone Cells
Epidermis / cytology,  pathology*
Histocompatibility Antigens Class II / immunology*
Hypersensitivity, Delayed / immunology
Lymphokines / biosynthesis*
Mice, Inbred C57BL
Mice, Inbred Strains
T-Lymphocytes / immunology,  transplantation*
T-Lymphocytes, Cytotoxic / metabolism*,  pathology
Transplantation, Isogeneic
Grant Support
Reg. No./Substance:
0/Histocompatibility Antigens Class II; 0/Lymphokines; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relationship between cell differentiation and binding of fluorescein isothiocyanate (FITC)-conjugate...
Next Document:  Selective suppression of two postnatally acquired 70 kD and 65 kD keratin proteins during continuous...