| Lichen striatus in adults and pimecrolimus: open, off-label clinical study. | |
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MedLine Citation:
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PMID: 18613885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Lichen striatus is a well-known, acquired, self-healing, linear inflammatory dermatosis. Lichen striatus occurring in adults tends to be more extensive and itchy than in children, sometimes requiring symptomatic treatment. The therapeutic approach usually adopted is topical steroids, even though prolonged use may lead to several side-effects, particularly cutaneous atrophy. OBJECTIVE: To report the results of an open, off-label study on the use of pimecrolimus 1% in the treatment of diffuse, nonresponsive forms of lichen striatus. METHODS: Three adult patients suffering from relapsing or disseminated and itchy lichen striatus received topical application of pimecrolimus 1% cream (Elidel, Novartis Pharma, Basle, Switzerland) twice daily for 6 weeks, or until complete disappearance of the cutaneous lesions. RESULTS: All patients experienced rapid healing of the dermatosis, without any recurrence for at least 14 months. CONCLUSION: Our preliminary results show that pimecrolimus may represent a useful therapeutic alternative for lichen striatus, although further studies on a larger number of cases are needed to confirm its safety and efficacy in the treatment of this condition. |
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Authors:
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Anna Campanati; Giuliano Brandozzi; Mirella Giangiacomi; Oriana Simonetti; Barbara Marconi; Anna Maria Offidani |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 47 ISSN: 1365-4632 ISO Abbreviation: Int. J. Dermatol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-10 Completed Date: 2008-09-30 Revised Date: 2009-03-05 |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 732-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology and Institute of Anatomopathology, Faculty of Medicine, Marche Polytechnic University, Ancona, Italy. a.campanati@ao-umbertoprimo.marche.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aged Biopsy, Needle Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Humans Immunohistochemistry Lichen Planus / drug therapy*, pathology* Severity of Illness Index Tacrolimus / administration & dosage, analogs & derivatives* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/pimecrolimus; 109581-93-3/Tacrolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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