| Lichen planus of the esophagus: What dermatologists need to know. | |
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MedLine Citation:
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PMID: 21536343 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Esophageal lichen planus (ELP) is a rare manifestation of mucocutaneous lichen planus (LP). OBJECTIVES: We aimed to report our experience and review all cases of ELP reported in the English-language literature. METHODS: We report our experience with 4 cases and reviewed PubMed for reports of ELP. Cases were evaluated for age of onset, sex, location of LP, relationship of the onset of ELP to extra-ELP, endoscopic findings, whether biopsy was performed, histopathology of esophageal biopsy specimens, medical history (including gastrointestinal history), development of esophageal squamous cell carcinoma, therapies tried, and response to treatment. RESULTS: A total of 72 cases of ELP were studied. In all, 87% of patients were female, with a median age of 61.9 years at time of diagnosis. Dysphagia was present in 81% and odynophagia was present in 24%. Oral LP was present in 89%, anogenital/vulvar LP in 42%, and cutaneous LP in 38%. Fourteen patients developed ELP as the sole or first manifestation of LP. Proximal esophageal lesions were present in 64%, distal in 11%, and both proximal and distal in 26%. Histology was "consistent with" LP in 71%. Four patients developed squamous cell carcinoma in association with ELP. LIMITATIONS: This is a review of our cases and others reported in the literature. CONCLUSIONS: ELP is underrecognized and underreported. There is often a significant delay between the onset of symptoms and the diagnosis. Malignant transformation of ELP to squamous cell carcinoma has been reported. |
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Authors:
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Lindy Peta Fox; Charles J Lightdale; Marc E Grossman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-30 |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: - ISSN: 1097-6787 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Dermatology, University of California, San Francisco, Columbia University Medical Center, New York. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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