Document Detail

Lichen planus and chronic hepatitis C: exacerbation of the lichen under interferon-alpha-2a therapy.
MedLine Citation:
PMID:  8864684     Owner:  NLM     Status:  MEDLINE    
A 51-year-old man was treated for histologically proven chronic hepatitis C with 3 MU of recombinant interferon-alpha-2a three times a week. Before interferon therapy, a mild lichen planus (hypertrophic variant) had been diagnosed, which exacerbated within 6 weeks of treatment to a severe erosive oral form. Then interferon therapy was stopped because local measures did not improve oral lesions. However, the patient tolerated interferon therapy well, and the initially four-fold elevated aminotransferase levels returned to normal. Nine weeks after discontinuation of interferon therapy, nearly all the buccal mucous membrane lesions had disappeared. But 8 weeks after withdrawal of interferon, aminotransferase levels rose again to six times the normal range. Treating physicians should know that a pre-existing lichen planus would potentially exacerbate, as a side effect of interferon-alpha-2a therapy of chronic hepatitis. However, further observations are needed to decide its clinical relevance.
J Areias; G C Velho; R Cerqueira; C Barbêdo; B Amaral; M Sanches; A Massa; A M Saraiva
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  8     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-08     Completed Date:  1997-01-08     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  825-8     Citation Subset:  IM    
Department of Gastroenterology, Hospital Geral de Santo António, Oporto, Portugal.
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MeSH Terms
Antiviral Agents / adverse effects*,  therapeutic use*
Chronic Disease
Disease Progression
Hepatitis C / drug therapy*
Interferon Alfa-2a / adverse effects*,  therapeutic use*
Lichen Planus, Oral / chemically induced*
Middle Aged
Reg. No./Substance:
0/Antiviral Agents; 76543-88-9/Interferon Alfa-2a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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