Document Detail

Lichen sclerosus and atopy in boys: coincidence or correlation?
MedLine Citation:
PMID:  22860989     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Lichen sclerosus (LS) is a sclerosing skin disease of presumably autoimmune origin affecting mainly the anogenital area. The aetiology is not completely understood. Comorbidity between genital LS and atopy in girls has been described but so far no controlled study has been performed.
OBJECTIVES: A prospective epidemiological case-control study was designed to clarify if there is comorbidity between genital LS and atopic skin diathesis (AD) in boys.
METHODS: The study included a total of 92 boys aged between 1 and 17 years. The disease group consisted of 48 boys who underwent surgery for phimosis that was histologically confirmed as LS. The control group included 44 boys who were circumcised for phimosis for other medical reasons. Both groups were examined and the parents were interviewed following the criteria of the validated Diepgen atopy score. Patients with a score > 9 were assumed to have AD.
RESULTS: Within the LS group (median age 8·7 years) 12 boys were diagnosed with AD (25%), while there were only three boys with AD (7%) in the control group (median age 5·3 years). The difference was significant using an age-adjusted logistic regression (P < 0·05). Prior to our study nine boys of the LS group (19%) and four boys of the control group (9%) had already been diagnosed with AD.
CONCLUSIONS: We have demonstrated a significant comorbidity between LS and AD in boys. AD seems to be a priming precondition for the development of LS in boys.
K Becker; V Meissner; W Farwick; R Bauer; M R Gaiser
Related Documents :
8326749 - Quantitative analysis of the cervical sympathetic trunk in young adult and aged rats.
20182419 - Interactions between age, stress and insulin on cognition: implications for alzheimer's...
2293609 - Development of haloperidol-induced dopamine release in the rat striatum using intracere...
7151919 - Plasticity of the aging cerebral cortex.
14601149 - Effects of aging on neurons and glial cells from the superficial layers of the superior...
11786479 - Endothelium-dependent hyperpolarization and relaxation in mesenteric arteries of middle...
18578529 - Photovoltage mechanism for room light conversion of citrate stabilized silver nanocryst...
24482109 - Sarcopenia and its relationship with osteoarthritis: risk factor or direct consequence?
9184599 - Incidence of epilepsy in rural central ethiopia.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of dermatology     Volume:  168     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-07-18     Revised Date:  2013-11-22    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. BJD © 2012 British Association of Dermatologists.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Balanitis / surgery
Case-Control Studies
Child, Preschool
Circumcision, Male
Dermatitis, Atopic / complications*
Genital Diseases, Male / etiology*
Lichen Sclerosus et Atrophicus / etiology*
Phimosis / surgery
Pilot Projects
Prospective Studies
Comment In:
Br J Dermatol. 2013 Oct;169(4):953-4   [PMID:  23909607 ]
Br J Dermatol. 2013 Oct;169(4):953   [PMID:  23909578 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dentition, dental health habits, and dementia: the Leisure World Cohort Study.
Next Document:  Arterial anatomic variations and its influence on transradial coronary procedural outcome.