| Lichen Planus-Like Drug Eruptions Due to β-Blockers: A Case Report and Literature Review. | |
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MedLine Citation:
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PMID: 22809321 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lichen planus-like drug eruptions (LDE) can appear similar or identical to idiopathic lichen planus. We present a 45-year-old man with a widespread, violaceous, papular, generalized exanthema with histologic features of a lichenoid reaction, which subsequently resolved with the cessation of labetatol. We found 29 cases of previously reported β-adrenoceptor antagonist (β-blocker)-associated LDE. This is a relatively rare complication that may present as classic lichenoid papules indistinguishable from lichen planus and has a predilection for the limbs, chest, back, and oral mucosa. Histologically, there is a lichenoid infiltrate often with eosinophils. LDE may be due to drug cross-reactivity or as a result of a suppressed skin adrenergic system. Multiple potential medications in case studies and the inability to differentiate LDE from idiopathic lichen planus in cross-sectional association studies make any conclusive analysis difficult. |
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Authors:
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Chris Fessa; Penny Lim; Steve Kossard; Shawn Richards; Pablo Fernandez Peñas |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-18 |
Journal Detail:
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Title: American journal of clinical dermatology Volume: - ISSN: 1175-0561 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100895290 Medline TA: Am J Clin Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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