Document Detail


Liberation of hydrogen from gastric acid following administration of oral magnesium.
MedLine Citation:
PMID:  2998715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We are in the process of developing a noninvasive test for gastric acid secretion based on the reaction of orally administered magnesium metal with gastric acid: Mg + 2HCl in equilibrium with MgCl2 + H2. We hypothesized that the hydrogen gas thus evolved could be detected in exhaled air and belches and that the amount of hydrogen released could be related to the amount of acid in the stomach. To validate this hypothesis, we gave magnesium to two groups of young adult volunteers following either betazole stimulation or cimetidine inhibition of acid secretion. In group I we gave subcutaneous betazole and gave magnesium in doses from 10 to 200 mg. In group II we gave oral betazole and used a constant dose of 150 mg of magnesium. In both groups we consistently detected significant increases in breath and belch hydrogen following magnesium in the betazole-stimulated volunteers. This response was blocked by cimetidine. The magnitude of the response was related to the magnesium dose, with 150 mg appearing to induce a maximum response. Administration of oral magnesium up to 200 mg was not associated with any untoward effects. We conclude that magnesium led to the release of hydrogen gas in vivo and that the quantity of hydrogen gas recovered was related to the amount of gastric acid. With further development, this principle might be used to develop a simple noninvasive test for gastric acid secretion.
Authors:
D A Sack; C B Stephensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  30     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-07     Completed Date:  1986-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1127-33     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Betazole / adverse effects,  pharmacology
Bicarbonates / pharmacology
Breath Tests
Cimetidine / pharmacology
Dose-Response Relationship, Drug
Gastric Acid / secretion*
Gastric Acidity Determination
Humans
Hydrogen / analysis*
Magnesium / diagnostic use*
Sodium / pharmacology
Sodium Bicarbonate
Time Factors
Chemical
Reg. No./Substance:
0/Bicarbonates; 105-20-4/Betazole; 1333-74-0/Hydrogen; 144-55-8/Sodium Bicarbonate; 51481-61-9/Cimetidine; 7439-95-4/Magnesium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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