Document Detail

LiCl and CCK inhibit gastric emptying and feeding and stimulate OT secretion in rats.
MedLine Citation:
PMID:  2537039     Owner:  NLM     Status:  MEDLINE    
Systemic injection of the nauseogenic agent LiCl is known to increase neurohypophyseal secretion of oxytocin (OT) in rats. The present results indicated that the induced OT secretion was related exponentially to the inhibition of food intake. A similar relation between OT secretion and food intake also was observed after systemic injection of the peptide hormone cholecystokinin (CCK). However, the effects of each agent on food intake lasted much longer than the observed increases in OT secretion. In contrast, both LiCl and CCK produced a dose-dependent inhibition of gastric emptying in rats that was closely related temporally to the inhibition of food intake. The similarity of these three responses to LiCl and CCK suggests that both agents stimulate common central mechanisms, apparently involving both magnocellular and parvocellular neurons in the paraventricular nucleus of the hypothalamus, whereby these neuroendocrine, behavioral, and autonomic functions are integrated.
M J McCann; J G Verbalis; E M Stricker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  256     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R463-8     Citation Subset:  IM    
Department of Behavioral Neuroscience, University of Pittsburgh, Pennsylvania 15260.
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MeSH Terms
Chlorides / pharmacology*
Cholecystokinin / pharmacology*
Feeding Behavior / drug effects*
Gastric Emptying / drug effects*
Lithium / pharmacology*
Lithium Chloride
Oxytocin / blood,  secretion*
Rats, Inbred Strains
Reference Values
Grant Support
Reg. No./Substance:
0/Chlorides; 50-56-6/Oxytocin; 7439-93-2/Lithium; 7447-41-8/Lithium Chloride; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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