Document Detail


Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients.
MedLine Citation:
PMID:  9458099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of doses of the secretor (Se) and Lewis (Le) genes on the serum levels of CA19-9 and DU-PAN-2 was investigated in 400 normal individuals. It was clearly demonstrated that the Se gene dosage negatively affected both the CA19-9 and DU-PAN-2 values, whereas the Le gene dosage positively affected the CA19-9 value and negatively affected the DU-PAN-2 value. The 400 normal individuals were separated into nine groups by their Le and Se genotypes, as follows: group 1, Le/Le and se/se; group 2, Le/le and se/se; group 3, Le/Le and Se/se; group 4, Le/le and Se/se; group 5, Le/Le and Se/Se; group 6, Le/le and Se/Se; group 7, le/le and se/se; group 8, le/le and Se/se; and group 9, le/le and Se/Se. The group 1 individuals, having homozygous inactive Se alleles (se/se) and homozygous active Le alleles (Le/Le), exhibited the highest mean CA19-9 value. The CA19-9 value clearly ranged from a high in group 1 to a low in group 9. All of the Le-negative individuals who had the le/le genotype (groups 7, 8, and 9) had completely negative CA19-9 values, i.e., under 1.0 unit/ml, irrespective of the Se genotype. Group 7 individuals (le/le and se/se) showed a higher mean DU-PAN-2 value than did individuals in other groups. The Le-negative individuals in groups 8 and 9 also showed a higher mean DU-PAN-2 value than did the Le-positive individuals in groups 1-6. We recommend that the revised Le and Se genotype-dependent positive/negative cutoff values for CA19-9 and DU-PAN-2, determined in this study, be applied for more accurate cancer diagnoses. The Le and Se genotypes of 168 patients with colorectal cancer were also examined, and the CA19-9 and DU-PAN-2 values were measured before surgical resection. All 15 Le-negative patients (le/le) with colorectal cancer again showed undetectable CA19-9 values, i.e., under 1.0 unit/ml, but many of them exhibited highly positive DU-PAN-2 values. In contrast, many of the Le-positive patients (Le/Le or Le/le) had positive CA19-9 values, whereas very few of them exhibited positive DU-PAN-2 values. CA19-9 measurement is more useful than is DU-PAN-2 measurement for Le-positive patients, but it is not useful for Le-negative ones. DU-PAN-2 measurement should be performed in Le-negative patients for cancer diagnosis.
Authors:
H Narimatsu; H Iwasaki; F Nakayama; Y Ikehara; T Kudo; S Nishihara; K Sugano; H Okura; S Fujita; S Hirohashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  58     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-02-24     Completed Date:  1998-02-24     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  512-8     Citation Subset:  IM    
Affiliation:
Division of Cell Biology, Institute of Life Science, Soka University, Hachioji, Toyko, Japan. hisashi@scc1.t.soka.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Alleles
Antigens, Neoplasm / blood*,  metabolism
CA-19-9 Antigen / blood*,  metabolism
Carbohydrate Sequence
Colorectal Neoplasms / blood*,  genetics
Epitopes / genetics,  metabolism
Fucosyltransferases / genetics*
Gene Dosage
Genotype
Glycosylation
Humans
Molecular Sequence Data
Neoplasm Proteins / blood*,  metabolism
Phenotype
Protein Processing, Post-Translational / genetics*
Tumor Markers, Biological / blood*,  metabolism
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/CA-19-9 Antigen; 0/DU-PAN-2 antigen, human; 0/Epitopes; 0/Neoplasm Proteins; 0/Tumor Markers, Biological; EC 2.4.1.-/Fucosyltransferases; EC 2.4.1.65/3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase; EC 2.4.1.69/galactoside 2-alpha-L-fucosyltransferase

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