Document Detail

Lewis-Sumner syndrome associated with infliximab therapy in rheumatoid arthritis.
MedLine Citation:
PMID:  18671292     Owner:  NLM     Status:  MEDLINE    
We report 2 cases of Lewis-Sumner syndrome (LSS) diagnosed in patients suffering from rheumatoid arthritis undergoing treatment with the antitumor necrosis factor alpha (TNF-alpha) monoclonal antibody infliximab. While experiencing clinical improvement in their arthritic symptoms, both patients experienced sensory deficits and weakness in multiple nerve distributions. They had electrodiagnostic evidence of motor conduction block and subsequent improvement with intravenous immunoglobulin (IVIg). We describe the details of the cases and review the literature on immune-mediated neuropathies associated with anti-TNF-alpha therapy.
Davyd R Hooper; Mark A Tarnopolsky; Steven K Baker
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  38     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-30     Completed Date:  2008-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1318-25     Citation Subset:  IM    
Department of Medicine, Neuromuscular Disease Clinic, Rm. 2H22, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5.
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MeSH Terms
Antibodies, Monoclonal / adverse effects*
Antirheumatic Agents / adverse effects
Arthritis, Rheumatoid / drug therapy*
Autoimmunity / drug effects,  immunology
Evoked Potentials / drug effects,  immunology
Immunoglobulins, Intravenous / therapeutic use
Middle Aged
Motor Neurons / drug effects,  immunology
Neural Conduction / drug effects,  immunology
Peripheral Nerves / drug effects,  immunology,  physiopathology
Peripheral Nervous System Diseases / chemically induced*,  immunology*,  physiopathology
Polyradiculoneuropathy / chemically induced*,  immunology*,  physiopathology
Sensory Receptor Cells / drug effects,  immunology
Treatment Outcome
Tumor Necrosis Factor-alpha / antagonists & inhibitors,  immunology
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antirheumatic Agents; 0/Immunoglobulins, Intravenous; 0/Tumor Necrosis Factor-alpha; 0/infliximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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