| Lewis-Sumner syndrome associated with infliximab therapy in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 18671292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report 2 cases of Lewis-Sumner syndrome (LSS) diagnosed in patients suffering from rheumatoid arthritis undergoing treatment with the antitumor necrosis factor alpha (TNF-alpha) monoclonal antibody infliximab. While experiencing clinical improvement in their arthritic symptoms, both patients experienced sensory deficits and weakness in multiple nerve distributions. They had electrodiagnostic evidence of motor conduction block and subsequent improvement with intravenous immunoglobulin (IVIg). We describe the details of the cases and review the literature on immune-mediated neuropathies associated with anti-TNF-alpha therapy. |
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Authors:
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Davyd R Hooper; Mark A Tarnopolsky; Steven K Baker |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 38 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-30 Completed Date: 2008-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 1318-25 Citation Subset: IM |
Affiliation:
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Department of Medicine, Neuromuscular Disease Clinic, Rm. 2H22, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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adverse effects* Antirheumatic Agents / adverse effects Arthritis, Rheumatoid / drug therapy* Autoimmunity / drug effects, immunology Electrodiagnosis Evoked Potentials / drug effects, immunology Female Humans Immunoglobulins, Intravenous / therapeutic use Male Middle Aged Motor Neurons / drug effects, immunology Neural Conduction / drug effects, immunology Peripheral Nerves / drug effects, immunology, physiopathology Peripheral Nervous System Diseases / chemically induced*, immunology*, physiopathology Polyradiculoneuropathy / chemically induced*, immunology*, physiopathology Sensory Receptor Cells / drug effects, immunology Syndrome Treatment Outcome Tumor Necrosis Factor-alpha / antagonists & inhibitors, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antirheumatic Agents; 0/Immunoglobulins, Intravenous; 0/Tumor Necrosis Factor-alpha; 0/infliximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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