| Levothyroxine treatment in pregnancy: indications, efficacy, and therapeutic regimen. | |
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MedLine Citation:
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PMID: 21876837 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The prevalence of overt and subclinical hypothyroidism during pregnancy is estimated to be 0.3-0.5% and 2-3%, respectively. Thyroid autoantibodies are found in 5-18% of women in the childbearing age. The aim of this review is to underscore the clinical significance of these findings on the health of both the mother and her offspring. Methods of evaluation of thyroid function tests (TFTs) during pregnancy are described as are the threshold values for the diagnosis of overt and subclinical hypothyroidism or hypothyroxinemia. Anticipated differences in TFTs in iodine-sufficient and iodine-deficient areas are discussed and data are provided on potential complications of hypothyroidism/hypothyroxinemia and autoimmune thyroid disease during pregnancy and adverse effects for the offspring. The beneficial effects of levothyroxine therapy on pregnancy outcomes and offspring development are discussed with a proposed treatment regimen and follow up strategy. |
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Authors:
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Joanna Klubo-Gwiezdzinska; Kenneth D Burman; Douglas Van Nostrand; Leonard Wartofsky |
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Publication Detail:
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Type: Journal Article Date: 2011-08-25 |
Journal Detail:
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Title: Journal of thyroid research Volume: 2011 ISSN: 2042-0072 ISO Abbreviation: J Thyroid Res Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101536655 Medline TA: J Thyroid Res Country: United States |
Other Details:
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Languages: eng Pagination: 843591 Citation Subset: - |
Affiliation:
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Section of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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