| Levothyroxine therapy in preventing nodular recurrence after hemithyroidectomy: a retrospective study. | |
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MedLine Citation:
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PMID: 19636201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine the effect of levothyroxine (L-T4) therapy on the recurrence rate of nodular disease in patients previously treated with lobectomy for benign nodular goiter. METHODS: Two hundred and thirty-tree patients (38 males, 195 females; age 49.9+/-13.1 yr) with no post-surgical evidence of nodular disease in the remnant, were followed- up yearly with serum TSH and ultrasound (US). Nodular recurrence was defined as a lesion of at least 5 mm at US. Patients were divided in 2 groups based on whether or not they had been treated with L-T4 after surgery: Group 1 (45 patients) who did not receive any L-T4, and Group 2 (188 patients) treated with L-T4. Group 2 was further subdivided in Group 2a (123 patients) receiving L-T4 substitutive therapy (TSH>or=0.5 and <or=3 mUI/l) and Group 2b (65 patients) receiving L-T4 at TSH-suppressive dose (TSH<0.5 mUI/l). RESULTS: Mean observation period was 5.8+/-4.7 yr. Overall, 71 out of 233 (30.5%) patients experienced recurrence of thyroid nodular disease: 29 patients (64.4%) in Group 1, 24 (19.5%) patients in Group 2a, and 18 (27.7%) patients in Group 2b. The recurrence rate was significantly lower (p<0.001) in Group 2 compared with Group 1, but no significant difference was observed between Groups 2a and 2b. CONCLUSION: In patients who have undergone hemithyroidectomy for benign monolobar nodular disease, L-T4 therapy may prevent recurrence of nodular disease. TSH suppression may not be required for prevention of recurrence in the remnant thyroid tissue. |
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Authors:
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M Alba; D Fintini; R M Lovicu; R M Paragliola; G Papi; C A Rota; A Pontecorvi; S M Corsello |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 32 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-07-28 Completed Date: 2009-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 330-4 Citation Subset: IM |
Affiliation:
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Endocrinology Unit, Catholic University of Sacred Heart, Via Federico Cesi, 72, 00193 Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Goiter, Nodular / drug therapy*, surgery Humans Male Middle Aged Neoplasm Recurrence, Local / prevention & control*, surgery Retrospective Studies Risk Factors Thyroid Neoplasms / drug therapy*, surgery Thyroidectomy* Thyroxine / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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