Document Detail

Levosimendan and severe pulmonary hypertension during open heart surgery.
MedLine Citation:
PMID:  19002758     Owner:  NLM     Status:  MEDLINE    
Weaning from cardiopulmonary bypass is the most important stage during mitral valve surgery, especially in patients with severe pulmonary hypertension. We report two patients with severe pulmonary hypertension who were operated on because of valvular heart disease. To reduce the pulmonary artery pressure, levosimendan was used because of its vasodilatory and cytoprotective effects. All patients tolerated the operation and levosimendan administration. Their postoperative course was uneventful. Levosimendan can be used to treat pulmonary hypertension during operations for heart valve disease. Patients clearly benefit from the vasodilator action of the drug for reducing pulmonary artery pressure.
Ferit Cicekcioglu; Ali Ihsan Parlar; Ozgur Ersoy; Kerem Yay; Alaa Hijazi; S Fehmi Katircioglu
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article     Date:  2008-11-12
Journal Detail:
Title:  General thoracic and cardiovascular surgery     Volume:  56     ISSN:  1863-6705     ISO Abbreviation:  -     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101303952     Medline TA:  Gen Thorac Cardiovasc Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  563-5     Citation Subset:  IM    
Kalp ve Damar Cerrahisi Klinigi (Cardiovascular Surgery Clinic), Turkiye Yuksek Ihtisas Hastanesi, Sihhiye, Ankara 06100, Turkey.
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MeSH Terms
Cardiac Surgical Procedures*
Follow-Up Studies
Heart Valve Diseases / surgery*
Heart Valve Prosthesis Implantation
Hydrazones / administration & dosage,  therapeutic use*
Hypertension, Pulmonary / drug therapy*
Middle Aged
Pyridazines / administration & dosage,  therapeutic use*
Time Factors
Treatment Outcome
Vasodilator Agents / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Hydrazones; 0/Pyridazines; 0/Vasodilator Agents; 131741-08-7/simendan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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