Document Detail

Levosimendan: a review of its use in the management of acute decompensated heart failure.
MedLine Citation:
PMID:  14636085     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Intravenous levosimendan is an effective calcium-sensitising drug with vasodilatory and inotropic effects, and superior efficacy/tolerability to those of intravenous dobutamine in patients with acute decompensated heart failure. It may be associated with reduced mortality compared with both placebo and dobutamine. Levosimendan is generally well tolerated and may have less potential for cardiac rate/rhythm disorders than dobutamine. While evidence from well designed trials confirming the improved mortality over dobutamine and investigating haemodynamic efficacy and mortality versus other positive inotropes is required, intravenous levosimendan appears to be a useful addition to the treatment options for acute decompensated heart failure in patients with low cardiac output.
Carmen A Innes; Antona J Wagstaff
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  63     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2003  
Date Detail:
Created Date:  2003-11-25     Completed Date:  2004-04-29     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  2651-71     Citation Subset:  IM    
Adis International Limited, Auckland, New Zealand.
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MeSH Terms
Acute Disease
Cardiotonic Agents / pharmacokinetics,  pharmacology,  therapeutic use*
Heart Failure / drug therapy*
Hemodynamics / drug effects
Hydrazones / pharmacokinetics,  pharmacology,  therapeutic use*
Pyridazines / pharmacokinetics,  pharmacology,  therapeutic use*
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Cardiotonic Agents; 0/Hydrazones; 0/Pyridazines; 349552KRHK/simendan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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