| Levosimendan: a review of its use in the management of acute decompensated heart failure. | |
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MedLine Citation:
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PMID: 14636085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: Intravenous levosimendan is an effective calcium-sensitising drug with vasodilatory and inotropic effects, and superior efficacy/tolerability to those of intravenous dobutamine in patients with acute decompensated heart failure. It may be associated with reduced mortality compared with both placebo and dobutamine. Levosimendan is generally well tolerated and may have less potential for cardiac rate/rhythm disorders than dobutamine. While evidence from well designed trials confirming the improved mortality over dobutamine and investigating haemodynamic efficacy and mortality versus other positive inotropes is required, intravenous levosimendan appears to be a useful addition to the treatment options for acute decompensated heart failure in patients with low cardiac output. |
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Authors:
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Carmen A Innes; Antona J Wagstaff |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 63 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 2003 |
Date Detail:
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Created Date: 2003-11-25 Completed Date: 2004-04-29 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: New Zealand |
Other Details:
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Languages: eng Pagination: 2651-71 Citation Subset: IM |
Affiliation:
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Adis International Limited, Auckland, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Cardiotonic Agents / pharmacokinetics, pharmacology, therapeutic use* Heart Failure / drug therapy* Hemodynamics / drug effects Humans Hydrazones / pharmacokinetics, pharmacology, therapeutic use* Pyridazines / pharmacokinetics, pharmacology, therapeutic use* Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Hydrazones; 0/Pyridazines; 349552KRHK/simendan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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