| Levosimendan produces an additional clinical and hemodynamic benefit in patients with decompensated heart failure successfully submitted to a fluid removal treatment. | |
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MedLine Citation:
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PMID: 22277178 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A pivotal role in treating decompensated heart failure (HF) is played by inotropes and calcium sensitizers such as levosimendan. In this study, the authors evaluated whether levosimendan could determine further clinical and hemodynamic benefits in 31 HF patients (New York Heart Association [NYHA] class III or IV), after successful treatment with diuretics (n=15) or ultrafiltration (n=16). Systolic, diastolic, dicrotic, and mean arterial pressures; systemic vascular resistance (SVR); some classic hemodynamic variables (cardiac output [CO], stroke volume [SV], dP/dt(max) ); and indices of cardiovascular system performance (cardiac cycle efficiency [CCE], cardiac power output) have been assessed by the pressure recording analytical method (PRAM), a minimally invasive monitoring system, before levosimendan infusion, at the end of treatment (EoT), and 36 hours after EoT (post-36). A significant increase in CCE, CO, SV, and dP/dt(max) and a significant decrease in diastolic and dicrotic arterial pressures and in SVR have been observed at EoT and at post-36. After the addition of levosimendan, a further reduction in signs and symptoms of HF and NYHA class was observed. Five patients showed an opposite trend of several hemodynamic parameters without any significant clinical improvement (nonresponders). In conclusion, most HF patients treated with diuretics or ultrafiltration receive additional clinical and hemodynamic benefits from levosimendan. The characterization of nonresponders could help in optimizing its use. Congest Heart Fail. 2012;18:47-53. ©2011 Wiley Periodicals, Inc. |
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Authors:
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Cristina Giglioli; Emanuele Cecchi; Daniele Landi; Marco Chiostri; Valentina Spini; Serafina Valente; Gian F Gensini; Salvatore M Romano |
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Publication Detail:
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Type: Journal Article Date: 2011-11-12 |
Journal Detail:
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Title: Congestive heart failure (Greenwich, Conn.) Volume: 18 ISSN: 1751-7133 ISO Abbreviation: Congest Heart Fail Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 47-53 Citation Subset: IM |
Copyright Information:
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© 2011 Wiley Periodicals, Inc. |
Affiliation:
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From the Medical and Surgical Cardiac Step Down Unit, Department of Heart and Vessels, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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