| Levosimendan for patients with impaired left ventricular function undergoing cardiac surgery. | |
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MedLine Citation:
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PMID: 17670579 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The efficacy of levosimendan treatment for a low cardiac output status following cardiac surgery has not been established. Here, we review our initial experiences of the perioperative use of levosimendan. This study is a retrospective uncontrolled trial. Nine patients who underwent cardiac surgery, and developed a low cardiac output status resistant to conventional inotropic support, were given levosimendan. The mean preoperative ejection fraction was 35.2+/-3.4%. All patients were on concomitant inotropic agents and had previously undergone intra-aortic balloon pumping. Cardiac index increased immediately from 2.14+/-0.33 l/min/m(2) at baseline to 2.41+/-0.31 (P=0.02) at 1 h, rising to 2.67+/-0.43 (P<0.001) at 4 h after the loading dose was started. Similarly, the systemic vascular resistance index decreased from 2350+/-525 dynes/s/cm(-5)/m(2) at baseline to 1774+/-360 (P=0.002) at 4 h. In the case of all but one of the patients, either the dose of the concomitant inotropic support or the balloon pumping could be weaned down within 24 h after completion of the levosimendan infusion. No withdrawal of levosimendan was required. Levosimendan could constitute a new therapeutic option for postoperative low cardiac output. |
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Authors:
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Yoshiyuki Tokuda; Peter W Grant; Hugh D Wolfenden; Con Manganas; William J Lyon; John S K Murala |
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Publication Detail:
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Type: Journal Article Date: 2006-03-23 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 5 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2007-08-02 Completed Date: 2007-08-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 322-6 Citation Subset: - |
Affiliation:
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Department of Cardiothoracic Surgery, Prince of Wales Hospital, Barker Street, Randwick, New South Wales, 2031, Australia. tokuda@mxb.mesh.ne.jp |
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| Comments/Corrections | |
Comment In:
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Interact Cardiovasc Thorac Surg. 2006 Jun;5(3):326
[PMID:
17670581
]
Interact Cardiovasc Thorac Surg. 2006 Jun;5(3):326 [PMID: 17670580 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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