Document Detail

Levosimendan for patients with impaired left ventricular function undergoing cardiac surgery.
MedLine Citation:
PMID:  17670579     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The efficacy of levosimendan treatment for a low cardiac output status following cardiac surgery has not been established. Here, we review our initial experiences of the perioperative use of levosimendan. This study is a retrospective uncontrolled trial. Nine patients who underwent cardiac surgery, and developed a low cardiac output status resistant to conventional inotropic support, were given levosimendan. The mean preoperative ejection fraction was 35.2+/-3.4%. All patients were on concomitant inotropic agents and had previously undergone intra-aortic balloon pumping. Cardiac index increased immediately from 2.14+/-0.33 l/min/m(2) at baseline to 2.41+/-0.31 (P=0.02) at 1 h, rising to 2.67+/-0.43 (P<0.001) at 4 h after the loading dose was started. Similarly, the systemic vascular resistance index decreased from 2350+/-525 dynes/s/cm(-5)/m(2) at baseline to 1774+/-360 (P=0.002) at 4 h. In the case of all but one of the patients, either the dose of the concomitant inotropic support or the balloon pumping could be weaned down within 24 h after completion of the levosimendan infusion. No withdrawal of levosimendan was required. Levosimendan could constitute a new therapeutic option for postoperative low cardiac output.
Yoshiyuki Tokuda; Peter W Grant; Hugh D Wolfenden; Con Manganas; William J Lyon; John S K Murala
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Publication Detail:
Type:  Journal Article     Date:  2006-03-23
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  5     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-08-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  322-6     Citation Subset:  -    
Department of Cardiothoracic Surgery, Prince of Wales Hospital, Barker Street, Randwick, New South Wales, 2031, Australia.
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Comment In:
Interact Cardiovasc Thorac Surg. 2006 Jun;5(3):326   [PMID:  17670581 ]
Interact Cardiovasc Thorac Surg. 2006 Jun;5(3):326   [PMID:  17670580 ]

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