Document Detail


Levosimendan in the treatment of cardiogenic shock.
MedLine Citation:
PMID:  20938415     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Patients with cardiogenic shock (CS) are currently treated with acute coronary revascularization, mechanical support (i.e., IABP), and in addition with vasopressor and inotropic support. Among medical treatment dobutamine and norepinephrine are drugs of first choice. Nowadays, intravenous levosimendan, a new calcium sensitizer and K-ATP channel opener, has emerged as an alternative option of pharmacologic inotropic support in patients with cardiogenic shock. Recent reports on levosimendan's use in cardiogenic shock demonstrated more favorable effects when compared with conventional inotropic agents. Clearly, levosimendan is able to archieve profound increase of cardiac index and cardiac power index in combination with reduced systemic and pulmonary resistance reduction compared to conventional therapy. Further, levosimendan is able to improve hemodynamic parameters more rapidly compared to intraaortic ballon counter pulsation. Similar, in patients with low cardiac output syndrome upon cardiovascular surgery, levosimendan is able to improve cardiac performance when administered prior or after cardiac surgery. In the light of cardiogenic shock, the myocardial protective effects of levosimendan might be important to reduce reperfusion injury and myocardial stunning following ischemia and reperfusion. This review summarizes the evidence from current scientific literature including our recent trials regarding the mechanism of action, efficiency and the use of levosimendan in CS patients.
Authors:
Buerkem Buerkem; H Lemm; K Krohe; S Dietz; U Raaz; U Buerke; M Russ; A Schlitt; K Werdan
Related Documents :
7245495 - Mechanical circulatory assistance for postoperative cardiogenic shock: a three year exp...
7847435 - Increase of myocardial inhibitory g-proteins in catecholamine-refractory septic shock o...
1781765 - Phenomenon of the adaptive stabilization of sarcoplasmic and nuclear structures in myoc...
2594615 - Haemodynamic effects of inosine. a new drug for failing human heart?
23558815 - Long-term survivor diagnosed with arrhythmogenic right ventricular cardiomyopathy/dyspl...
15459465 - Correlation of plasma concentrations of b-type natriuretic peptide with infarct size qu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  58     ISSN:  0026-4725     ISO Abbreviation:  Minerva Cardioangiol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  519-30     Citation Subset:  IM    
Affiliation:
Department of Medicine III, Martin-Luther-University, Halle, Germany - michael.buerke@medizin.uni-halle.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacological testing in the diagnosis of arrhythmias.
Next Document:  Effects of metformin and short-term lifestyle modification on the improvement of male hypogonadism a...