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Levosimendan attenuates hypoxia-induced pulmonary hypertension in a porcine model.
MedLine Citation:
PMID:  22240915     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Levosimendan was hypothesized to attenuate hypoxic pulmonary vasoconstriction (HPV). METHODS: 14 anaesthetized pigs (30,9±1,0kg) were studied in normoxia (FiO2∼0,21) and hypoxia (FiO2∼0,10), before and 10-90 min after infusion of placebo (n=7) or Levosimendan (n=7). RESULTS: Compared to normoxia, hypoxia-baseline at FiO2∼0,10 (n=14) increased PVR by 1.9±0.4 WU (p<0,001), MPAP by 14.3±0.9 mmHg (p<0,001), MRAP by 2.1±0.4 mmHg (p<0,001), PCWP by 1.5±0.3 mmHg (p<0,001), CO by 1.3±0.2 L·min (p<0,001) and HR by 19.9±5.5 beats·min (p<0,001). SVR decreased by 7,2±1.0 WU (p<0,001), MAP and SV remained unaltered (p=ns). Compared to hypoxia-baseline, Levosimendan decreased MPAP and PVR (p<0,05), by ∼9 and ∼19%, respectively, plateauing between 10-90 min. SV increased (p<0,05) by ∼22%, plateauing after 60 min. MRAP, PCWP, HR, CO, MAP, SVR and blood-O2-consumption remained unaltered (p=ns). Compared to hypoxia-baseline, with placebo, MPAP remained stable (p=ns), PVR increased (p<0,05) and CO decreased (p<0,05), by ∼20 and ∼11% after 60-90 and 30-90min, respectively. SV decreased (p<0,05) by ∼8%, plateauing after 60-90min. PCWP and MRAP decreased (p<0,05) by ∼12%, plateauing after 10-60 and 10-90min, respectively. MPAP, HR, MAP, SVR and blood-O2-consumption remained unchanged (p=ns), except at 60min where MAP decreased (p<0,05) by ∼4%. CONCLUSIONS: Levosimendan attenuated HPV and the cardio-depressive effect of sustained hypoxia.
Authors:
Annaeva Wiklund; David Kylhammar; Göran Rådegran
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-11
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1The Öresund Cardiovascular Research Collaboration, The Clinic for Heart Failure and Valvular Disease, Skåne University Hospital and, The Department of Cardiology, IKVL, Lund University, Lund, Sweden 2The Copenhagen Muscle Research Centre, Rigshospitalet and the Panum Institute, University of Copenhagen, Copenhagen, Denmark.
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