Document Detail


Levosimendan Versus Intra-aortic Balloon Pump in High-Risk Cardiac Surgery Patients.
MedLine Citation:
PMID:  21546269     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Patients with severe left ventricular dysfunction receive inotropic and mechanical circulatory support with an intra-aortic balloon pump (IABP) during the perioperative phase of cardiac surgery. The authors performed the first comparison of levosimendan versus an IABP in patients with poor left ventricular function undergoing cardiac surgery. DESIGN: A case-matched study. SETTING: A teaching hospital. PARTICIPANTS: Twenty-two heart failure patients scheduled to undergo elective coronary artery bypass graft surgery with or without concomitant mitral surgery. INTERVENTIONS: Eleven patients received levosimendan at a dose of 0.1 μg/kg/min for 24 hours without an initial bolus. The control group, also 11 patients, received a preoperative IABP. The intensive care unit stay was the major endpoint of this study. Biochemical, hemodynamic, and echocardiographic data were collected together with the time on mechanical ventilation and 30-day mortality. MEASUREMENTS AND MAIN RESULTS: The length of intensive care unit stay was reduced in patients receiving levosimendan (median, 2.5; range, 1-3 days) compared with those receiving an IABP (median, 5; range, 3-6 days; p = 0.01). No deaths occurred in the levosimendan group; 1 patient died in the intra-aortic balloon pump group. CONCLUSIONS: Patients receiving levosimendan had a shorter duration of intensive care stay than peers who received a preoperative IABP. The findings of this pilot study should be investigated further in a large randomized controlled study.
Authors:
Luca Severi; Angela Lappa; Giovanni Landoni; Lucio Di Pirro; Sacha Jerome Luzzi; Patrizia Caravetta; Pierluigi Cipullo; Antonio Menichetti
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-3
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  -     ISSN:  1532-8422     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Cardiovascular Anaesthesia and Intensive Care Unit, Cardiovascular Department, San Camillo Hospital, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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