Document Detail

Levofloxacin-induced radiation recall dermatitis: a case report and a review of the literature.
MedLine Citation:
PMID:  20920986     Owner:  NLM     Status:  MEDLINE    
Radiation recall dermatitis (RRD) is a rare phenomenon. There are a few reports in the literature reporting RRD triggered by quinolones administration after external beam radiation therapy (EBRT). We present an unusual case of RRD induced by levofloxacin 7 months after completion of EBRT. A 56-year-old Caucasian female was treated with EBRT for stage I carcinoma of the right breast with whole breast irradiation followed by the boost to the tumor bed to a total dose of 6080 cGy. Seven months post completion of EBRT, levofloxacin was administered for an upper respiratory tract infection. On day 8 of levofloxacin, the patient developed a blistering RRD in the skin overlying the area of previous radiation portals. Discontinuation of the RRD-inducing antibiotic and appropriate therapy led to the resolution of the condition. We review literature emphasizing this quinolone antibiotic as a causative of RRD.
A Gabriella Wernicke; Alexander J Swistel; Bhupesh Parashar; Patricia L Myskowski
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical breast cancer     Volume:  10     ISSN:  1938-0666     ISO Abbreviation:  Clin. Breast Cancer     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898731     Medline TA:  Clin Breast Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  404-6     Citation Subset:  IM    
Stich Radiation Oncology, Weill Medical College of Cornell University, New York, NY 10065, USA.
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MeSH Terms
Anti-Bacterial Agents / adverse effects*,  therapeutic use
Breast Neoplasms / radiotherapy*,  surgery
Carcinoma, Lobular / radiotherapy*,  surgery
Middle Aged
Ofloxacin / adverse effects*,  therapeutic use
Radiodermatitis / chemically induced*
Radiotherapy, Adjuvant
Respiratory Tract Infections / drug therapy*
Reg. No./Substance:
0/Anti-Bacterial Agents; 82419-36-1/Ofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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