Document Detail

Levodopa influences the regularity of the ankle joint kinematics in individuals with Parkinson's disease.
MedLine Citation:
PMID:  19823927     Owner:  NLM     Status:  MEDLINE    
The aim of the investigation was to explore the influence of levodopa therapy on the regularity of the structural variations present in the lower extremity joints of individuals with Parkinson's disease (PD). Ten participants with PD walked on a treadmill during the states of "off" and "on" levodopa. Approximate entropy was used to quantify the regularity of the structural variations present in the joint kinematics. Additionally, a pseudo-periodic surrogation analysis was used to evaluate if changes in the regularity of the joint's movement were associated with a noisy or deterministic motor process. This investigation provided two key findings. The first was that the structural variations present in ankle joint were more regular with levodopa therapy. The second was that changes in the structural variations were related to a deterministic motor process. This indicated that the variations present in the walking patterns of individuals with PD most likely arose from higher-order neural couplings rather than noise in the motor process. Monitoring the regularity of the structural variations present in gait may help improve the management of PD.
Max J Kurz; Jyhgong Gabriel Hou
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Publication Detail:
Type:  Journal Article     Date:  2009-10-13
Journal Detail:
Title:  Journal of computational neuroscience     Volume:  28     ISSN:  1573-6873     ISO Abbreviation:  J Comput Neurosci     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9439510     Medline TA:  J Comput Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-6     Citation Subset:  IM    
Munroe-Meyer Institute for Genetics and Rehabilitation, Physical Therapy Department, University of Nebraska Medical Center, 985450 Nebraska Medical Center, Omaha, NE 68198-5450, USA.
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MeSH Terms
Ankle Joint / drug effects*,  physiopathology
Antiparkinson Agents / therapeutic use*
Hip Joint / drug effects,  physiopathology
Knee Joint / drug effects,  physiopathology
Levodopa / therapeutic use*
Motor Activity / drug effects*,  physiology
Parkinson Disease / drug therapy*,  physiopathology
Walking* / physiology
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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