| Levodopa-induced modulation of subthalamic beta oscillations during self-paced movements in patients with Parkinson's disease. | |
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MedLine Citation:
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PMID: 15813950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Excessive synchronization of neural activity in the beta frequency band ( approximately 20 Hz) within basal ganglia circuits might contribute to the paucity and slowness of movement in Parkinson's disease (PD). Treatment with dopaminergic drugs reduces the background level of beta frequency band synchronization in the subthalamic nucleus (STN), but has not been shown to increase the proportion of beta activity that is suppressed before voluntary movement in PD. We assessed changes in the event-related desynchronization (ERD) in the beta frequency band of local field potential signals from the region of the STN in 14 patients with PD as they performed self-paced movements of a joystick before and after levodopa administration. The dopamine precursor, levodopa, increased the duration and magnitude of the premovement beta ERD, but did not alter postmovement synchronization in the beta band. Both the latency and magnitude of the beta ERD inversely correlated with the degree of motor impairment. These findings suggest that the beta ERD recorded in the STN area reflects motor-preparative processes that are at least partly dependent on dopaminergic activity within the basal ganglia. |
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Authors:
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L M F Doyle; A A Kühn; M Hariz; A Kupsch; G-H Schneider; P Brown |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: The European journal of neuroscience Volume: 21 ISSN: 0953-816X ISO Abbreviation: Eur. J. Neurosci. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-04-07 Completed Date: 2005-05-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8918110 Medline TA: Eur J Neurosci Country: France |
Other Details:
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Languages: eng Pagination: 1403-12 Citation Subset: IM |
Affiliation:
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Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 8-11, Queen Square, London WC1N 3BG, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Beta Rhythm / drug effects* Dopamine Agents / therapeutic use* Female Humans Levodopa / therapeutic use* Magnetic Resonance Imaging / methods Male Middle Aged Parkinson Disease / drug therapy*, pathology, physiopathology Psychomotor Performance / drug effects*, physiology Reaction Time / drug effects Signal Processing, Computer-Assisted Statistics as Topic Subthalamic Nucleus / drug effects*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents; 0/Levodopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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