Document Detail

Levodopa in Huntingtons chorea.
MedLine Citation:
PMID:  131644     Owner:  NLM     Status:  MEDLINE    
Sixteen patients with Huntington's chorea were treated for periods as long as 8 months with levodopa. The condition of none of the patients improved; in fact, there appeared to be an exacerbation of chorea and dementia in addition to undesirable behavioural changes. Therefore, future use of levodopa in these patients is not warranted. The postulated association of low homovanillic acid values in cerebrospinal fluid and favourable response to levodopa therapy was not borne out.
S K Sishta; D I Templer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Medical Association journal     Volume:  114     ISSN:  0008-4409     ISO Abbreviation:  Can Med Assoc J     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0414110     Medline TA:  Can Med Assoc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  798-9     Citation Subset:  AIM; IM    
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MeSH Terms
Behavior / drug effects
Drug Administration Schedule
Homovanillic Acid / cerebrospinal fluid
Huntington Disease / cerebrospinal fluid,  drug therapy*
Hydroxyindoleacetic Acid / cerebrospinal fluid
Levodopa / adverse effects,  therapeutic use*
Long-Term Care
Middle Aged
Probenecid / diagnostic use
Reg. No./Substance:
0/Levodopa; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; 57-66-9/Probenecid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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