Document Detail

Levobunolol. A four-year study of efficacy and safety in glaucoma treatment. The Levobunolol Study Group.
MedLine Citation:
PMID:  2664628     Owner:  NLM     Status:  MEDLINE    
In a 4-year, double-masked, parallel, multicenter study comparing the efficacy and safety of levobunolol and timolol, 391 patients with open-angle glaucoma or ocular hypertension were randomly assigned to receive masked 0.5% or 1% levobunolol, or 0.5% timolol, twice daily. Mean decreases in intraocular pressure (IOP) over 4 years of therapy were 7.1, 7.2, and 7.0 mmHg for 0.5% levobunolol, 1% levobunolol, or 0.5% timolol, respectively. Little attenuation of ocular hypotensive efficacy occurred. The 4-year efficacy failure rate for the three groups, which did not differ from each other, was approximately 30%. Adverse experiences requiring cessation of therapy occurred in an additional 10% of patients. The vast majority of efficacy failures (79/95) and of adverse events (33/37) requiring removal from the study occurred during the first 2 years. Overall mean decreases in heart rate for the 4 years ranged from 3 to 6 beats per minute for all treatment groups; overall mean decreases in systolic and diastolic blood pressure ranged between 1 and 2 mmHg. The authors concluded that levobunolol is relatively effective and relatively safe for the long-term (4-year) treatment of elevated IOP.
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Ophthalmology     Volume:  96     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-08-18     Completed Date:  1989-08-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  642-5     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Clinical Trials as Topic
Double-Blind Method
Glaucoma, Open-Angle / drug therapy*
Heart Rate / drug effects
Intraocular Pressure / drug effects
Levobunolol / therapeutic use*
Longitudinal Studies
Middle Aged
Multicenter Studies as Topic
Ocular Hypertension / drug therapy*
Random Allocation
Time Factors
Timolol / therapeutic use
Visual Fields
Reg. No./Substance:
26839-75-8/Timolol; 47141-42-4/Levobunolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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