Document Detail

Levo-propionyl-carnitine improves the effectiveness of supervised physical training on the absolute claudication distance in patients with intermittent claudication.
MedLine Citation:
PMID:  18319227     Owner:  NLM     Status:  MEDLINE    
The mechanisms by which supervised physical training improves walking ability in patients with intermittent claudication (IC) are microcirculatory, rheological, and metabolic. The main mechanism of levo-propionylcarnitine (LPC) is metabolic; it increases the walking ability in claudicants, providing an additional energy to the ischemic muscle by an anaplerotic activity. Therefore, the current study was carried out to ascertain whether the combined treatment has a synergistic effect. The results confirm the effectiveness of supervised physical training in patients with IC, and we recommend the use of LPC during the exercise training program, at least in patients with severe claudication. Finally, underlining the similar mechanisms of physical training and LPC treatment, the study suggests that a cycle of LPC infusions could be advised in patients with severe claudication who cannot be included, for various reasons, in an exercise rehabilitation program.
Giuseppe Maria Andreozzi; Alfredo Leone; Rita Laudani; Romeo Martin; Gregorio Deinit; Valentina Cataldi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Angiology     Volume:  59     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2008 Feb-Mar
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  IM    
Angiology Care Unit of University Hospital of Padua, Italy.
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MeSH Terms
Carnitine / administration & dosage,  analogs & derivatives*,  therapeutic use
Combined Modality Therapy
Exercise Therapy*
Infusions, Intravenous
Intermittent Claudication / drug therapy,  metabolism,  physiopathology,  therapy*
Muscle, Skeletal / drug effects*,  metabolism,  physiopathology
Severity of Illness Index
Time Factors
Treatment Outcome
Reg. No./Substance:
17298-37-2/propionylcarnitine; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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