| Levitation and movement of human tumor cells using a printed circuit board device based on software-controlled dielectrophoresis. | |
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MedLine Citation:
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PMID: 12632404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study we describe an original, efficient, and innovative printed circuit board (PCB) device able to generate dielectrophoresis-based, software-controlled cages that can be moved to any place inside a microchamber. Depending on their dielectrophoretic properties, eukaryotic cells can be "entrapped" in cages and moved under software control. The main conclusion gathered from the experimental data reported is that the PCB device based on dielectrophoresis permits levitation and movement of different tumor cells at different dielectrophoresis conditions. The results presented herein are therefore the basis for experiments aimed at forced interactions or separation of eukaryotic cells using "lab-on-a-chip." In fact, because many cages can be controlled at the same time, and two or more cages can be forced to share the same or a different location, it is possible, in principle, either to bring in contact cells of a differing histotype or to separate them. |
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Authors:
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L Altomare; M Borgatti; G Medoro; N Manaresi; M Tartagni; R Guerrieri; R Gambari |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biotechnology and bioengineering Volume: 82 ISSN: 0006-3592 ISO Abbreviation: Biotechnol. Bioeng. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-03-12 Completed Date: 2003-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7502021 Medline TA: Biotechnol Bioeng Country: United States |
Other Details:
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Languages: eng Pagination: 474-9 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley Periodicals, Inc. Biotechnol Bioeng 82: 474-479, 2003. |
Affiliation:
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Center of Excellence on Electronic Systems (ARCES), University of Bologna, Bologna, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Cell Culture Techniques / instrumentation*, methods Cell Separation / instrumentation*, methods Electromagnetic Fields* Electrophoresis / instrumentation*, methods Equipment Design Equipment Failure Analysis Humans Jurkat Cells / radiation effects K562 Cells / radiation effects Leukemia Leukemia, Erythroblastic, Acute Melanoma Mice Microelectrodes Micromanipulation / instrumentation*, methods* Miniaturization Motion* Tumor Cells, Cultured / radiation effects User-Computer Interface |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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