Document Detail


Levitation and movement of human tumor cells using a printed circuit board device based on software-controlled dielectrophoresis.
MedLine Citation:
PMID:  12632404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we describe an original, efficient, and innovative printed circuit board (PCB) device able to generate dielectrophoresis-based, software-controlled cages that can be moved to any place inside a microchamber. Depending on their dielectrophoretic properties, eukaryotic cells can be "entrapped" in cages and moved under software control. The main conclusion gathered from the experimental data reported is that the PCB device based on dielectrophoresis permits levitation and movement of different tumor cells at different dielectrophoresis conditions. The results presented herein are therefore the basis for experiments aimed at forced interactions or separation of eukaryotic cells using "lab-on-a-chip." In fact, because many cages can be controlled at the same time, and two or more cages can be forced to share the same or a different location, it is possible, in principle, either to bring in contact cells of a differing histotype or to separate them.
Authors:
L Altomare; M Borgatti; G Medoro; N Manaresi; M Tartagni; R Guerrieri; R Gambari
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biotechnology and bioengineering     Volume:  82     ISSN:  0006-3592     ISO Abbreviation:  Biotechnol. Bioeng.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-03-12     Completed Date:  2003-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7502021     Medline TA:  Biotechnol Bioeng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  474-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley Periodicals, Inc. Biotechnol Bioeng 82: 474-479, 2003.
Affiliation:
Center of Excellence on Electronic Systems (ARCES), University of Bologna, Bologna, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Count
Cell Culture Techniques / instrumentation*,  methods
Cell Separation / instrumentation*,  methods
Electromagnetic Fields*
Electrophoresis / instrumentation*,  methods
Equipment Design
Equipment Failure Analysis
Humans
Jurkat Cells / radiation effects
K562 Cells / radiation effects
Leukemia
Leukemia, Erythroblastic, Acute
Melanoma
Mice
Microelectrodes
Micromanipulation / instrumentation*,  methods*
Miniaturization
Motion*
Tumor Cells, Cultured / radiation effects
User-Computer Interface

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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