Document Detail

Levetiracetam reduces frequency and duration of epileptic activity in patients with refractory primary generalized epilepsy.
MedLine Citation:
PMID:  16837220     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Levetiracetam (LEV) is a new antiepileptic drug highly effective as add-on treatment in refractory partial epilepsies. In animal models, LEV is effective against absence seizures. A limited number of case reports and series indicate that LEV reduces seizure frequency in patients with generalized epilepsies.
METHOD: We evaluated with continuous EEG eight adult patients with idiopathic generalized epilepsy (IGE). All patients were refractory to the conventional therapy for IGE. Four patients received LEV as add-on therapy, and in four, a conversion to LEV monotherapy was undergone. Epileptic activity was analyzed in order to determine spike-wave density as well as median and maximal duration of spike-wave discharges. Each patient underwent a 24h EEG baseline monitoring before starting LEV therapy. A second 24h EEG examination was performed after a mean follow-up period of 136 days.
RESULTS: Spike-wave density (spikes/h) was reduced by 78% after LEV administration. Median spike-wave duration decreased by 72% (p < 0.05). Maximal spike-wave duration was 6s before, and 1.5s after LEV with a percentage change of 81% (p < 0.05). The four patients on LEV monotherapy evidenced also a considerably improvement after conversion.
CONCLUSIONS: This study showed that LEV produces a consistent long-term reduction of interictal epileptic activity in patients with refractory IGE. The reduction in the spike-wave activity additionally correlated with a clinically relevant antiepileptic effect. Our results support the concept that LEV could be an alternative therapy in primary generalized epilepsies.
R Rocamora; K Wagner; A Schulze-Bonhage
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-11
Journal Detail:
Title:  Seizure     Volume:  15     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-10-17     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  428-33     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / therapeutic use*
Drug Therapy, Combination
Epilepsy, Generalized / drug therapy*,  physiopathology
Piracetam / analogs & derivatives*,  therapeutic use
Retrospective Studies
Seizures / drug therapy*
Reg. No./Substance:
0/Anticonvulsants; 230447L0GL/etiracetam; ZH516LNZ10/Piracetam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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