| Levetiracetam monotherapy for elderly patients with epilepsy. | |
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MedLine Citation:
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PMID: 14741184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We retrospectively identified 14 elderly patients with a history of partial seizures who received levetiracetam (LEV) monotherapy. Patients began LEV either as first line therapy (n=5) or were converted to LEV monotherapy (n=9) after failing prior antiepileptic medications (AEDs). Thirteen patients continued on LEV monotherapy for at least 6 months. One patient was lost to follow-up. Eight patients (61.5%) became seizure free. Four patients who began LEV as a first line therapy became seizure free, whereas the remaining four patients who converted to LEV after they failed their previous AEDs became seizure free. Four patients (30.7%) had more than a 50% seizure reduction of seizures. Only one patient had no significant change in seizure frequency after started on LEV. The total dosages used to control seizures were 500-3000 mg/day, (mean 1839.2 mg/day). LEV monotherapy can be effective and well tolerated in this group of patients. A prospective, larger, double blind monotherapy study is needed to confirm this finding. |
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Authors:
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Taoufik M Alsaadi; Suzanne Koopmans; Michelle Apperson; Sarah Farias |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Seizure : the journal of the British Epilepsy Association Volume: 13 ISSN: 1059-1311 ISO Abbreviation: Seizure Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-26 Completed Date: 2004-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306979 Medline TA: Seizure Country: England |
Other Details:
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Languages: eng Pagination: 58-60 Citation Subset: IM |
Affiliation:
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Department of Neurology, Epilepsy Treatment Center, University of California, Davis, Sacramento, CA 95817, USA. taoufik.alsaadi@ucdmc.ucdavis.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Anticonvulsants / therapeutic use* Dose-Response Relationship, Drug Epilepsy / drug therapy* Female Humans Male Middle Aged Piracetam / analogs & derivatives*, therapeutic use* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 33996-58-6/etiracetam; 7491-74-9/Piracetam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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