| Levetiracetam improves intention tremor in fragile x-associated tremor/ataxia syndrome. | |
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MedLine Citation:
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PMID: 19471185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fragile X-associated tremor/ataxia syndrome is a recently discovered disorder affecting more of one third of older adult male carriers of premutation alleles of fragile X mental retardation 1 (FMR1 gene). There is no established treatment.The 66-year-old right-handed grandfather of a boy with fragile X syndrome, a carrier of premutation alleles of FMR1 gene, developed an action tremor in his right hand when writing. His writing became large and completely illegible. Administration of levetiracetam was associated with subjective and objective improvement, and handwriting became possible again. Levetiracetam was well tolerated, and no adverse effects were reported. |
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Authors:
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Riccardo Saponara; Salvatore Greco; Giuliana Proto; Teresa Trubia; Elisabetta Domina |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical neuropharmacology Volume: 32 ISSN: 1537-162X ISO Abbreviation: Clin Neuropharmacol Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-05-27 Completed Date: 2009-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7607910 Medline TA: Clin Neuropharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 53-4 Citation Subset: IM |
Affiliation:
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Neurological Unit Private Hospital "Villa Mauritius" Siracusa, Italy. ricsaponara@inwind.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticonvulsants / therapeutic use* Ataxia / etiology* Family Health Fragile X Syndrome / complications* Humans Male Piracetam / analogs & derivatives*, therapeutic use Tremor / drug therapy*, etiology* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 33996-58-6/etiracetam; 7491-74-9/Piracetam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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