| Levetiracetam efficacy in patients with Lennox-Gastaut syndrome. Presentation of a case. | |
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MedLine Citation:
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PMID: 21353345 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: The Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies of childhood, characterized by electro-clinical triad of generalized spike-wave activity, slow (POL) in the electroencephalogram (EEG), multiple types of seizures and development delay. This paper intends to describe the syndrome in a patient with a history of hypoxic-ischaemic encephalopathy and Lennox-Gastaut syndrome, and a good response to treatment with levetiracetam (LEV). METHOD: Descriptive study on the development of a 3 year old child with intrauterine asphyxia, multiorgan failure, metabolic acidosis, hypovolemic shock, and seizures with cerebral oedema, who developed a West syndrome, resistant to drug treatment. The semiology of seizures progressively changed to generalized episodes of hypertonia and myoclonus, with slow spike-wave electroencephalographic activity. RESULTS: With the diagnosis of Lennox-Gastaut syndrome the patient was treated with levetiracetam, showing a substantial improvement in the cognitive sphere, in the control of seizures, and electroencephalographic findings. CONCLUSIONS: Lennox-Gastaut syndrome is one of the most severe epileptic syndromes in paediatric patients. Levetiracetam can help cognitive improvement, and contribute to seizure control in these patients. |
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Authors:
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A Díaz Negrillo; F Martín Del Valle; M González Salaices; C Prieto Jurczynska; J Carneado Ruiz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
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Title: Neurologia (Barcelona, Spain) Volume: - ISSN: 0213-4853 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005460 Medline TA: Neurologia Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Neurología, Hospital Infanta Elena, Valdemoro, Madrid, España. |
Vernacular Title:
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Eficacia del levetiracetam en pacientes con síndrome de Lennox-Gastaut. Presentación de un caso. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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