| Leveraging elevated temperature and particle size reduction to extract API from various tablet formulations. | |
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MedLine Citation:
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PMID: 18280688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several sample preparation techniques were evaluated for extracting active pharmaceutical ingredient (API) from immediate release (IR) and controlled release (CR) tablet formulations. These techniques utilized either elevated temperature [e.g., accelerated solvent extraction (ASE) and microwave assisted extraction (MAE)] or particle size reduction [e.g., ball mill and homogenizer/Tablet Processing Workstation II (TPWII)]. Results were compared for equivalence to those obtained with the existing standard method for each formulation. For the CR formulations, sample preparation times were significantly reduced when using these techniques compared to the standard method. Advantages and limitations associated with each technique are discussed. |
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Authors:
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Beverly Nickerson; William B Arikpo; Mark R Berry; Vincent J Bobin; Timothy L Houck; Hany L Mansour; John Warzeka |
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Publication Detail:
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Type: Journal Article Date: 2008-01-11 |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 47 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-12 Completed Date: 2008-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: England |
Other Details:
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Languages: eng Pagination: 268-78 Citation Subset: IM |
Affiliation:
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Pfizer Global Research & Development, Groton/New London Laboratories, Pfizer Inc, Groton, CT 06340, USA. beverly.nickerson@pfizer.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dosage Forms* Drug Compounding / instrumentation, methods* Particle Size Pharmaceutical Preparations / analysis* Tablets* Temperature |
| Chemical | |
Reg. No./Substance:
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0/Dosage Forms; 0/Pharmaceutical Preparations; 0/Tablets |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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