Document Detail


Levels of soluble forms of ICAM and VCAM in patients with myelodysplastic syndromes and their prognostic significance.
MedLine Citation:
PMID:  15595996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to assess circulating soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and interleukin-1beta (IL-1beta) in myelodysplastic syndromes (MDS) in order to evaluate their clinical significance. Seventy patients with untreated MDS [21 refractory anemia (RA), nine RA with ringed sideroblasts (RARS), 17 RA with excess of blasts (RAEB), 11 RAEB in transformation (RAEBt), and 12 chronic myelomonocytic leukemia (CMML)] were included in this study. Serum levels of sICAM, sVCAM, and IL-1beta were determined at diagnosis using commercially available immunoassays. In addition, 15 healthy volunteers were studied as a control group. sICAM, sVCAM, and IL-1beta serum levels were significantly higher in MDS patients in comparison with the control group (P <0.001). Patients with CMML showed the highest sICAM, sVCAM, and IL-1beta levels in comparison with other MDS-related subtypes. Furthermore significantly elevated levels of the studied parameters were detected in high-risk MDS patients (RAEB, RAEB-t, and CMML) in comparison with low-risk MDS (RA and RARS). IL-1beta was strongly correlated both to sICAM and sVCAM. In conclusion we have provided evidence that increased sICAM and sVCAM serum levels are related to MDS severity.
Authors:
F H Passam; G Tsirakis; A Boula; A Fragou; I Consolas; A Alegakis; D S Kyriakou; M G Alexandrakis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  26     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-14     Completed Date:  2005-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-5     Citation Subset:  IM    
Affiliation:
Haematology Unit, Third Department of Internal Medicine, Sotiria Hospital, Medical School of Athens, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Humans
Intercellular Adhesion Molecule-1 / blood*
Interleukin-1 / blood
Male
Middle Aged
Myelodysplastic Syndromes / blood,  diagnosis*
Prognosis
Solubility
Vascular Cell Adhesion Molecule-1 / blood*
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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