Document Detail


Levels of soluble CD163 and severity of malaria in children in Ghana.
MedLine Citation:
PMID:  18632918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD163 is an acute-phase-regulated monocyte/macrophage membrane receptor expressed late in inflammation. It is involved in the haptoglobin-mediated removal of free hemoglobin from plasma, has been identified as a naturally soluble plasma glycoprotein with potential anti-inflammatory properties, and is possibly linked to an individual's haptoglobin phenotype. High levels of soluble CD163 (sCD163) in a malaria episode may therefore downregulate inflammation and curb disease severity. In order to verify this, the relationships between sCD163 levels, malaria severity, and selected inflammatory mediators (tumor necrosis factor alpha [TNF-alpha], interleukin-6 [IL-6], and IL-10) were assessed by enzyme-linked immunosorbent assay using plasma samples obtained from pediatric malaria patients with uncomplicated malaria (UM [n = 38]), cerebral malaria (CM [n = 52]), and severe malarial anemia (SA [n = 55]) during two consecutive malaria transmission seasons (2002 and 2003). Median sCD163 levels were higher in UM (11.9 microg/ml) patients than in SA (7.7 microg/ml; P = 0.010) and CM (8.0 microg/ml; P = 0.031) patients. Levels of sCD163 were also higher in all patient groups than in a group of 81 age-matched healthy controls. The higher sCD163/TNF-alpha ratio in UM patients, coupled with the fact that sCD163 levels correlated with TNF-alpha levels in UM patients but not in CM and SA patients, suggests inflammatory dysregulation in the complicated cases. The study showed that sCD163 levels are elevated during acute malaria. High sCD163 levels in UM patients may be due to the induction of higher-level anti-inflammatory responses, enabling them to avoid disease complications. It is also possible that UM patients simply lost their CD163 receptors from macrophages in inflammatory sites while complicated-malaria patients still had their receptors attached to activated macrophages, reflecting ongoing and higher-level inflammation associated with complicated malaria.
Authors:
Kwadwo A Kusi; Ben A Gyan; Bamenla Q Goka; Daniel Dodoo; George Obeng-Adjei; Marita Troye-Blomberg; Bartholomew D Akanmori; Jonathan P Adjimani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-16
Journal Detail:
Title:  Clinical and vaccine immunology : CVI     Volume:  15     ISSN:  1556-679X     ISO Abbreviation:  Clin. Vaccine Immunol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-05     Completed Date:  2008-10-23     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  101252125     Medline TA:  Clin Vaccine Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1456-60     Citation Subset:  IM    
Affiliation:
Immunology Department, Noguchi Memorial Institute for Medical Research, P.O. Box LG581, University of Ghana, Legon, Ghana.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD / blood*
Antigens, Differentiation, Myelomonocytic / blood*
Case-Control Studies
Child
Child, Preschool
Cytokines / blood
Enzyme-Linked Immunosorbent Assay / methods
Ghana
Humans
Infant
Malaria / pathology*,  physiopathology*
Receptors, Cell Surface / blood*
Severity of Illness Index*
Statistics as Topic
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD163 antigen; 0/Cytokines; 0/Receptors, Cell Surface
Comments/Corrections

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