Document Detail

Levels of salivary stress markers in patients with anxiety about halitosis.
MedLine Citation:
PMID:  20807658     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To investigate the relationship between salivary stress markers and mental stress states in patients complaining of oral malodour. The utility of the salivary stress markers in assessment of mental conditions of those patients was also investigated.
DESIGN: The study population included 74 patients, aged 20-59 years, who complained of oral malodour and were referred to the Breath Odor Clinic at Tokushima University Hospital. Patients were classified into two groups, genuine halitosis (GH) and psychosomatic halitosis (PH), according to the results of organoleptic rating measurement. All patients were subjected to examination by the Cornell Medical Index (CMI) Health Questionnaire. Resting saliva was collected and levels of salivary IgA, cortisol and chromogranin A were determined by ELISA. Twenty-three volunteers not complaining of halitosis were included as the control group. Kruskal-Wallis test and Mann-Whitney's U-test were used for statistical analysis.
RESULTS: A significant increase was observed in the concentrations of salivary cortisol in the PH group as compared with GH and control groups (p<0.05). Concentrations of IgA and chromogranin A in saliva were not significantly different among the three groups. In addition, higher salivary cortisol concentrations were found in CMI scale III and IV (tendency towards neurosis) than in scale I and II (normal) (p<0.05). Since salivary cortisol reflects a status of chronic stress condition, psychosomatic halitosis might be closely related to this state of chronic stress.
CONCLUSIONS: Determination of cortisol levels in saliva may provide useful information for evaluating the mental status of patients complaining of halitosis.
Makoto Fukui; Daisuke Hinode; Masaaki Yokoyama; Masami Yoshioka; Kosuke Kataoka; Hiro-O Ito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of oral biology     Volume:  55     ISSN:  1879-1506     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  842-7     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramotocho, Japan.
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