| Levels of sVCAM-1 and sICAM-1 in patients with lyme disease. | |
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MedLine Citation:
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PMID: 19413177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Lyme disease is a multi-organ animal-borne disease caused by the spirochete Borrelia burgdorferi (Bb). OBJECTIVES: As the pathogenesis of Lyme borreliosis is not fully understood, the study has been designed to examine levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) in serum and the cerebrospinal fluid (CSF) of patients with Lyme borreliosis and their associations with clinical signs and symptoms and anti-Borrelia burgdorferi (anti-Bb) antibody titers. PATIENTS AND METHODS: Sixty-four patients were enrolled in the study, including 39 patients treated for Lyme borreliosis and 25 without the disease (control group). In both groups sVCAM-1 and sICAM-1 levels were determined in serum and the CSF. RESULTS: Mean serum sICAM-1 and sVCAM-1 levels were higher in patients with Lyme borreliosis than in the control group. Serum sICAM-1 levels were significantly lower among patients with results positive for immunoglobulin M seroreactivity with Bb than among those with negative antibody responses. In patients with Bb-specific serum immunoglobulin G (IgG) antibodies, significantly higher serum sICAM-1 levels were found. Higher sVCAM-1 and sICAM-1 levels in the CSF were observed in patients positive for anti-Bb IgG antibody titers in the CSF. CONCLUSIONS: In patients with Lyme borreliosis, endothelial cell activation results in elevated levels of sICAM-1 and sVCAM-1 in serum and the CSF. |
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Authors:
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Grazyna Biesiada; Jacek Czepiel; Iwona Sobczyk-Krupiarz; Dominika Salamon; Aleksander Garlicki; Tomasz Mach |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Polskie Archiwum Medycyny Wewn?trznej Volume: 119 ISSN: 0032-3772 ISO Abbreviation: Pol. Arch. Med. Wewn. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-05-05 Completed Date: 2009-07-14 Revised Date: 2010-04-01 |
Medline Journal Info:
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Nlm Unique ID: 0401225 Medline TA: Pol Arch Med Wewn Country: Poland |
Other Details:
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Languages: eng Pagination: 200-4 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Krak?w, Poland. gbiesiada@op.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood, cerebrospinal fluid Borrelia burgdorferi / immunology Cerebrospinal Fluid / immunology Female Humans Immunoglobulin G / metabolism Intercellular Adhesion Molecule-1 / blood* Lyme Disease / blood*, cerebrospinal fluid, diagnosis* Male Middle Aged Serologic Tests Vascular Cell Adhesion Molecule-1 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Immunoglobulin G; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1 |
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