Document Detail


Levels of sVCAM-1 and sICAM-1 in patients with lyme disease.
MedLine Citation:
PMID:  19413177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Lyme disease is a multi-organ animal-borne disease caused by the spirochete Borrelia burgdorferi (Bb). OBJECTIVES: As the pathogenesis of Lyme borreliosis is not fully understood, the study has been designed to examine levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) in serum and the cerebrospinal fluid (CSF) of patients with Lyme borreliosis and their associations with clinical signs and symptoms and anti-Borrelia burgdorferi (anti-Bb) antibody titers. PATIENTS AND METHODS: Sixty-four patients were enrolled in the study, including 39 patients treated for Lyme borreliosis and 25 without the disease (control group). In both groups sVCAM-1 and sICAM-1 levels were determined in serum and the CSF. RESULTS: Mean serum sICAM-1 and sVCAM-1 levels were higher in patients with Lyme borreliosis than in the control group. Serum sICAM-1 levels were significantly lower among patients with results positive for immunoglobulin M seroreactivity with Bb than among those with negative antibody responses. In patients with Bb-specific serum immunoglobulin G (IgG) antibodies, significantly higher serum sICAM-1 levels were found. Higher sVCAM-1 and sICAM-1 levels in the CSF were observed in patients positive for anti-Bb IgG antibody titers in the CSF. CONCLUSIONS: In patients with Lyme borreliosis, endothelial cell activation results in elevated levels of sICAM-1 and sVCAM-1 in serum and the CSF.
Authors:
Grazyna Biesiada; Jacek Czepiel; Iwona Sobczyk-Krupiarz; Dominika Salamon; Aleksander Garlicki; Tomasz Mach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewn?trznej     Volume:  119     ISSN:  0032-3772     ISO Abbreviation:  Pol. Arch. Med. Wewn.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-07-14     Revised Date:  2010-04-01    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  200-4     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Krak?w, Poland. gbiesiada@op.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood,  cerebrospinal fluid
Borrelia burgdorferi / immunology
Cerebrospinal Fluid / immunology
Female
Humans
Immunoglobulin G / metabolism
Intercellular Adhesion Molecule-1 / blood*
Lyme Disease / blood*,  cerebrospinal fluid,  diagnosis*
Male
Middle Aged
Serologic Tests
Vascular Cell Adhesion Molecule-1 / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Immunoglobulin G; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

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