| Levels of purine compounds in a perfusate as a biochemical marker of ischemic injury of cold-preserved liver. | |
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MedLine Citation:
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PMID: 3603677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biochemical markers of ischemic injury of rat liver were studied in an extracorporeal perfusion system. During anoxic perfusion, purine compounds appeared in the perfusate as soon as they were formed in the liver and their recovery in the perfusate balanced the loss of adenine nucleotides from the liver. In contrast, cytosolic aspartate aminotransferase did not appear in the perfusate at slow rates of liver perfusion or during hypothermic perfusion. The production of purine compounds was further investigated in hypothermically preserved liver in connection with the restoration of some metabolic functions of liver. The amount of purine compounds released into the perfusate was found to be closely related to the degrees of damage of the hepatic functions of gluconeogenesis, ureogenesis, and mitochondrial respiration on reperfusion. These results indicate that release of purine compounds into the perfusate is a good marker of ischemic damage. |
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Authors:
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T Nishida; M Koseki; W Kamiike; M Nakahara; K Nakao; Y Kawashima; T Hashimoto; K Tagawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplantation Volume: 44 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-08-24 Completed Date: 1987-08-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 16-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine Nucleotides
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analysis Animals Aspartate Aminotransferases / analysis Cold Temperature / adverse effects Gluconeogenesis Ischemia / etiology, metabolism* Liver / analysis*, blood supply Male Mitochondria / physiology Organ Preservation / adverse effects* Perfusion Purines / analysis* Rats Rats, Inbred Strains Urea / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Adenine Nucleotides; 0/Purines; 57-13-6/Urea; EC 2.6.1.1/Aspartate Aminotransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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