Document Detail


Levels of prostaglandin E2 and Cysteinyl-leukotrienes in sputum supernatant of patients with asthma: the effect of smoking.
MedLine Citation:
PMID:  23711123     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Smoking is associated with worse asthma outcomes and may modify airway inflammation. Such modification may be mediated through an effect on prostaglandin E2 (PGE2 ) and cysteinyl leukotrienes (Cyst-LTs).
OBJECTIVE: We aimed to determine the levels of both PGE2 and Cyst-LTs in sputum supernatants of patients with asthma and to investigate the effect of smoking habit as well as their associations with inflammatory cells, bronchial hyperresponsiveness (BHR) and lung function.
METHODS: Ninety-eight patients to asthma (47 smokers) and 40 healthy subjects (20 smokers) were studied. All subjects underwent sputum induction for cell count identification, PGE2 and Cyst-LTs levels measurement in supernatants, pulmonary function tests and BHR to methacholine.
RESULTS: Patients with asthma had significantly higher levels of both Cyst-LTs and PGE2 in sputum supernatants compared to healthy subjects [median (interquartile ranges) 432 (287, 575) vs. 91.5 (73.5, 111) pg/mL and 654 (456,789) vs. 117.5 (92,157) pg/mL, respectively, P < 0.001 for both comparisons]. Smoking asthmatics had significantly higher Cyst-LTs and PGE2 levels compared to non-smoking asthmatics. Cyst-LTs levels in sputum supernatant of smoking asthmatics presented a significant positive association with sputum eosinophils, while PGE2 levels were positively associated with sputum neutrophils.
CONCLUSIONS: The increased concentrations of PGE2 and Cyst-LTs in sputum supernatants of smoking asthma are consistent with an up-regulation of these two mediators in this specific phenotype of asthma. Furthermore, Cyst-LTs are associated with eosinophilic inflammation, while PGE2 is associated with the presence of neutrophilic inflammation in smoking asthma.
Authors:
K Kontogianni; P Bakakos; K Kostikas; G Hillas; A Papaporfyriou; S Papiris; N G Koulouris; S Loukides
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  43     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  616-24     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons Ltd.
Affiliation:
1st Respiratory Medicine Department, University of Athens Medical School, 'Sotiria' Chest Hospital, Athens, Greece.
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