Document Detail


Levels of proelafin peptides in the sera of the patients with generalized pustular psoriasis and pustulosis palmoplantaris.
MedLine Citation:
PMID:  10877128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels of proelafin peptides in the sera of patients with pustulosis palmoplantaris, a unique type of localized pustular psoriasis, and generalized pustular psoriasis were determined by competitive enzyme-linked immunosorbent assays using antibodies against synthetic proelafin polypeptides corresponding to the elastase inhibitor (elafin) and transglutaminase substrate domains. The sera of patients with pustulosis palmoplantaris (9 cases) exhibited a normal range of proelafin peptide levels. The sera of patients with generalized pustular psoriasis (3 cases) showed high titres of proelafin peptide. There were no large differences in the titres between the 2 antibodies. The antibodies for 2 different domains of proelafin showed a similar immunoreactivity for the non-pustular region of the epidermis in all pustulosis palmoplantaris tested. The results indicate that serum proelafin peptides in pustular psoriasis may depend on the extent of the involved area, and that proelafin peptide level in pustulosis palmoplantaris remains normal despite enhanced local expression in the lesional skin. Since the skin lesions of patients with pustulosis palmoplantaris are limited to the palms and soles, enhanced expression of proelafin in the lesional skin may not lead to elevation of proelafin peptides in the serum.
Authors:
N Tanaka; A Fujioka; S Tajima; A Ishibashi; S Hirose
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  80     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2000-11-07     Completed Date:  2000-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  102-5     Citation Subset:  IM    
Affiliation:
Department of Dermatology, National Defense Medical College, Saitama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / analysis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunohistochemistry
Male
Middle Aged
Proteinase Inhibitory Proteins, Secretory
Proteins / pharmacokinetics*
Psoriasis / blood*,  drug therapy*,  pathology
Reference Values
Sensitivity and Specificity
Serine Proteinase Inhibitors / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Proteinase Inhibitory Proteins, Secretory; 0/Proteins; 0/Serine Proteinase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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