Document Detail

Levels of polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like polychlorinated biphenyls in placentas from the Spanish INMA birth cohort study.
MedLine Citation:
PMID:  23134768     Owner:  NLM     Status:  Publisher    
Because fetuses are considered significantly more sensitive to various environment toxicants, there is a need for continuous biomonitoring of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls PCBs (DL-PCBs) to assess their impact on this susceptible population. The aim of this study was to assess the concentration of PCDD/Fs and DL-PCBs in placenta samples from women participating in the Spanish Environment and Childhood (INMA) birth cohort study and to evaluate whether maternal and child characteristics predict placenta concentrations of these pollutants. The presence of PCDD/Fs and DL-PCBs was investigated in 50 placenta samples selected at random in the recruitment period 2000-2008. Multivariable regression models were constructed. Mothers had a mean age at delivery of 30.7years (18.0-38.0years), pre-pregnancy BMI of 23.3kg/m(2) (18.0-40.2kg/m(2)), and 31% were smokers. Median total concentrations of PCDD/Fs and DL-PCBs were 6.9pgWHO-TEQ/g lipid and 2.1pgWHO-TEQ/g lipid, respectively. In comparison to the few previous studies in placenta, total TEQ levels were among the lowest recorded in comparable general populations. The congener distribution pattern and the frequencies and concentrations of PCDD/F and DL-PCB congeners were similar to previous reports in placenta. PCDD/F and DL-PCB exposure was related to the age of the mother and the year of the delivery. Although placental concentrations cannot be considered wholly appropriate predictors for evaluating fetal exposure to these contaminants, they can provide a good indication of both maternal and infant prenatal and postnatal exposure and can be used as a proxy for fetal exposure.
Mariana F Fernandez; Jordi Parera; Juan P Arrebola; Loreto Santa Marina; Martine Vrijheid; Sabrina Llop; Manoli Abalos; Adonina Tardon; Argelia Castaño; Esteban Abad; Nicolas Olea
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-4
Journal Detail:
Title:  The Science of the total environment     Volume:  441C     ISSN:  1879-1026     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  -    
Other Details:
Languages:  ENG     Pagination:  49-56     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Biomedical Research Center, University of Granada, Laboratory of Medical Investigations, San Cecilio University Hospital; Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address:
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