| Levels of interleukin (IL)-6, IL-8, and IL-1 receptor antagonist in the hepatic vein following liver surgery. | |
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MedLine Citation:
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PMID: 11020876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The liver produces various cytokines, but local changes in the concentrations of these reaction products after liver surgery are unknown. We investigated the local changes of interleukin-6, interleukin-8 and interleukin-1 receptor antagonist after liver surgery. METHODOLOGY: We determined levels of interleukin-6, interleukin-8, and interleukin-1 receptor antagonist in the hepatic vein and radial artery after liver resection in 13 patients. These cytokine levels in the portal vein were also measured in 6 patients. RESULTS: Interleukin-6, interleukin-8, and interleukin-1 receptor antagonist levels were significantly increased during liver surgery (P < 0.05). The level of interleukin-6 was significantly lower in the hepatic vein than in the radial artery as well as in the portal vein at the end of the operation (P < 0.05, < 0.03). The level of interleukin-8 and interleukin-1 receptor antagonist was significantly higher in the hepatic vein than in the artery (P < 0.05). CONCLUSIONS: Interleukin-6 may be taken up by the liver after liver surgery, and the difference between hepatic venous and peripheral arterial interleukin-6 levels may be an indicator of liver regeneration after liver resection. Interleukin-8 and interleukin-1 receptor antagonist appear to be produced in the remaining liver. |
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Authors:
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T Ueda; T Sakabe; M Oka; Y Maeda; M Nishida; F Murakami; T Maekawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 47 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2000 Jul-Aug |
Date Detail:
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Created Date: 2001-02-02 Completed Date: 2001-02-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: GREECE |
Other Details:
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Languages: eng Pagination: 1048-51 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology-Resuscitology, Yamaguchi University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Electrocoagulation Enzyme-Linked Immunosorbent Assay Female Hepatectomy Hepatic Artery / metabolism* Hepatic Veins / metabolism* Humans Interleukin 1 Receptor Antagonist Protein Interleukin-6 / blood* Interleukin-8 / blood* Liver Neoplasms / blood, surgery* Male Microwaves Middle Aged Portal Vein / metabolism Radial Artery Sialoglycoproteins / blood* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-6; 0/Interleukin-8; 0/Sialoglycoproteins |
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