Document Detail

Levels of gastrin-cholecystokinin-like immunoreactivity in the brains of genetically obese and non-obese rats.
MedLine Citation:
PMID:  7243623     Owner:  NLM     Status:  MEDLINE    
Levels of gastrin-cholecystokinin-like immunoreactivity were measured in three brain regions (cortex, diencephalon, brainstem) and the pituitary gland in groups of genetically obese Zucker rats and their non-obese littermates. The obese animals had significantly increased body weights and significantly lowered brain weights. However, levels of gastrin-cholecystokinin-like immunoreactivity were not different between the two groups in any of the regions measured. These results contrast with a recent report [11] in which ob/ob mice were found to have decreased levels of cholecystokinin in their brains.
J A Finkelstein; A W Steggles
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  2     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1981  
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-21     Citation Subset:  IM    
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MeSH Terms
Body Weight
Brain Chemistry*
Brain Stem / analysis
Cerebral Cortex / analysis
Cholecystokinin / analysis*
Diencephalon / analysis
Gastrins / analysis*
Obesity / metabolism*
Organ Size
Pituitary Gland / analysis
Rats, Inbred Strains
Species Specificity
Tissue Distribution
Grant Support
Reg. No./Substance:
0/Gastrins; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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