| Levels of fetuin-A relate to the levels of bone turnover biomarkers in male and female patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 21958193 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To evaluate the relationship of plasma fetuin-A levels with markers of bone turnover in male and female type 2 diabetic subjects. Background: Fetuin-A, which is a serum protein produced by the liver and promotes bone mineralization, is an independent risk factor for type 2 diabetes, whilst type 2 diabetes is associated with an increased incidence of osteoporosis or fractures. It is not known how fetuin-A levels relate to parameters of bone metabolism in type 2 diabetes. Design and patients: 80 type 2 diabetic patients (40 males and 40 females matched for age, body mass index (BMI) and time since diagnosis of diabetes) were studied. Fetuin-A together with metabolic parameters and levels of serum carboxy-terminal telopeptide of type 1 collagen (C-telopeptide), osteocalcin, procollagen type 1 amino-terminal propeptide (P1NP), bone alkaline phosphatase (ALP), and sex hormones were determined in all participants. Results: Fetuin-A levels did not differ significantly between male and female diabetic subjects. In a model adjusted for age, BMI, fatty liver index (FLI), time since diagnosis of diabetes, HbA(1c) , anti-diabetic and lipid-lowering drug therapies, smoking, total serum protein, creatinine, gamma glutamyl-transferase, parathyroid hormone, C-reactive protein, glomerular filtration rate, and presence of micro-, cardio-, and peripheral vascular diabetic complications, fetuin-A showed a significant positive association with levels of bone ALP (r= 0.71, p= 0.006) in males. In females, fetuin-A was significantly negatively associated with C-telopeptide (r= - 0.60, p= 0.03) levels. Conclusions: Results suggest an independent association of fetuin-A levels with markers of bone turnover in male and female type 2 diabetic patients. More studies are needed to determine whether fetuin-A could serve as a new marker for fracture risk or osteoporosis in type 2 diabetes and to explore its potential sexually dimorphic effects. |
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Authors:
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Sazan Rasul; Aysegul Ilhan; Marie Helene Reiter; Jelena Todoric; Serdar Farhan; Harald Esterbauer; Alexandra Kautzky-Willer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-29 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Internal Medicine III, Division of Endocrinology and Metabolism, Unit of Gender medicine Department of Medical and Chemical Laboratory Diagnostics Department of Internal Medicine III, Division of Nephrology and Dialysis Medical University of Vienna, Vienna, Austria Department of Cardiology and Emergency Medicine, Wilhelminen Hospital, Vienna, Austria. |
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