| Levels of expression of CAF7 (CD98) have prognostic significance in adult acute leukemia. | |
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MedLine Citation:
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PMID: 9585078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The levels of CD98 antigen expression were studied in 62 consecutive cases of adult acute leukemia including 24 acute lymphoblastic leukemia (ALL) and 38 acute myeloid leukemia (AML) using the monoclonal antibody CAF7 and flow cytometry. The mean follow-up was 13.5 months. The mean relative fluorescence intensity (MIF) of CAF7 varied between 6 and 83 channels (256 channels resolution). No correlation was established between CAF7 cell surface density and most of the predictive parameters such as age, sex, blood counts, immunophenotype, proliferative index (PI) or DNA index. Nevertheless expression of CAF7 correlated positively with survival duration (mean 210 vs 391 days, P = 0.048) and complete remission (CR) duration (mean 132 vs 361, days P = 0.032). The levels of CAF7 differed significantly between ALL and AML (P < 0.001), the ALL cases being all CAF7intermediate or CAF7high. In the AML group the low levels of CAF7 expression correlated with shorter CR duration (mean 132 vs 414 days, P = 0.017). The lack of correlation with other clinical and biological parameters suggested that CAF7 might have an independent prognostic significance in adult AML. Although PI was also positively related to survival duration (P = 0.02), it did not correlate with CR duration or the expression of CAF7. We suppose that the prognostic impact of CD98 is related to the control of cell growth and survival in which the molecule normally participates. |
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Authors:
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M Nikolova; M Guenova; H Taskov; E Dimitrova; M Staneva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Leukemia research Volume: 22 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-05-26 Completed Date: 1998-05-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 39-47 Citation Subset: IM |
Affiliation:
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Department of Immunology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Antigens, CD / biosynthesis, immunology* Antigens, CD98 Carrier Proteins / biosynthesis, immunology* Female Humans Leukemia, Myeloid / immunology*, physiopathology* Male Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology*, mortality, physiopathology* Prognosis Survival Analysis Tumor Markers, Biological* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD98; 0/Carrier Proteins; 0/Tumor Markers, Biological |
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