| Levels of ethyl glucuronide and ethyl sulfate in oral fluid, blood, and urine after use of mouthwash and ingestion of nonalcoholic wine. | |
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MedLine Citation:
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PMID: 20223100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study is to investigate the concentrations of ethyl glucuronide (EtG) in oral fluid and both EtG and ethyl sulfate (EtS) in blood and urine following intense use of mouthwash and ingestion of nonalcoholic wine, which are proven to contain 3 mg/L EtG, 1.5 mg/L EtS, and 0.2 g/L ethanol. Twelve subjects participated in a controlled experiment. All subjects ingesting nonalcoholic wine showed urine samples negative for EtG but positive for EtS (Cmax 2.15 mg/L). All four subjects using mouthwash were negative for EtG and EtS in urine. All samples of oral fluid were negative for EtG and all samples of blood were negative for EtG and EtS. This study showed that ingestion of EtG and EtS as components of nonalcoholic wine lead to detection of urine EtS only, suggesting superior bioavailability of orally ingested EtS compared to EtG. This possibility of false-positive EtS results in urine after ingestion of nonalcoholic wine is important to remember when using EtG and EtS as relapse markers for alcohol. Finally, the study showed that a positive EtG or EtS result after accidental alcohol exposure is unlikely in blood and oral fluid. |
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Authors:
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Gudrun Høiseth; Borghild Yttredal; Ritva Karinen; Hallvard Gjerde; Asbjørg Christophersen |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 34 ISSN: 1945-2403 ISO Abbreviation: J Anal Toxicol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-12 Completed Date: 2010-09-22 Revised Date: 2011-05-10 |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 84-8 Citation Subset: IM |
Affiliation:
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Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway. Gudrun.Hoiseth@fhi.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking / blood, metabolism, urine Alcoholic Beverages Biological Markers / analysis, blood, urine Creatinine / blood False Positive Reactions Female Glucuronates / administration & dosage, analysis*, blood, urine Humans Male Mouthwashes / administration & dosage*, chemistry* Saliva / chemistry* Sulfuric Acid Esters / administration & dosage, analysis*, blood, urine Wine / analysis* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Glucuronates; 0/Mouthwashes; 0/Sulfuric Acid Esters; 17685-04-0/ethyl glucuronide; 60-27-5/Creatinine; 64-67-5/diethyl sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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