Document Detail

Levels of circulating tumor-associated glycoprotein (TAG-72) in patients with carcinoma using a novel tumor marker, CA 72-4
MedLine Citation:
PMID:  3166366     Owner:  NLM     Status:  MEDLINE    
CA72-4 is a novel quantitative immunoradiometric assay system utilizing two monoclonal antibodies CC-49 and B72.3, which recognize a tumor-associated glycoprotein (TAG-72). We have utilized the CA72-4 RIA kit to measure serum levels of TAG-72 in 205 patients with carcinoma and 192 patients without carcinoma. The cut-off value (4.0 U/ml) was obtained according to the levels and the distribution of CA72-4 in 468 healthy individuals. The positive rates in 82 patients with gastric cancer, 55 with colorectal cancer, 24 with pancreatico-choledochal cancer, 36 with breast cancer, and 3 with ovarian cancer were 52%, 55%, 46%, 39%, and 67%, respectively. Fifty percent of the sera from 205 patients with carcinoma demonstrated increased levels of CA72-4, whereas only 10% of the sera from 192 patients without evidence of malignancy showed levels more than 4.0 U/ml. The average level of serum CA72-4 in the patients with carcinoma was 38.6 U/ml, much higher than that (2.7 U/ml) in patients without malignancy. The patients with gastrointestinal cancer at advanced stages or at recurrence showed higher levels of serum CA72-4 than the patients with cancer at early stages. These results thus indicate that CA72-4 is clinically useful as a novel tumor marker, especially for monitoring serum levels of TAG-72 in patients with gastrointestinal cancer, breast cancer, ovarian cancer and other epithelial malignancies.
N Ohuchi; N Matoba; Y Taira; K Takahashi; N Sakai; K Sato; N Fujita; F Mochizuki; T Nishihira; S Mori
Publication Detail:
Type:  English Abstract; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gan to kagaku ryoho. Cancer & chemotherapy     Volume:  15     ISSN:  0385-0684     ISO Abbreviation:  Gan To Kagaku Ryoho     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-13     Completed Date:  1988-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7810034     Medline TA:  Gan To Kagaku Ryoho     Country:  JAPAN    
Other Details:
Languages:  jpn     Pagination:  2767-72     Citation Subset:  IM    
Dept. of Surgery, Sendai City Hospital, Japan.
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MeSH Terms
Antigens, Neoplasm / analysis*
Antigens, Tumor-Associated, Carbohydrate
Breast Neoplasms / immunology
Carcinoembryonic Antigen / analysis
Gastrointestinal Neoplasms / immunology
Neoplasms / immunology*
Radioimmunoassay / methods
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antigens, Tumor-Associated, Carbohydrate; 0/Carcinoembryonic Antigen; 0/Tumor Markers, Biological

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