Document Detail

Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients.
MedLine Citation:
PMID:  19681661     Owner:  NLM     Status:  MEDLINE    
As traditional risk factors are unable to fully explain the pathogenesis of coronary artery disease (CAD), novel mechanisms became a target of many investigations. Our aim was to study the response of selected markers to physical exercise. High-sensitive C-reactive protein (hs-CRP), matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), advanced oxidation protein products (AOPP), soluble receptor for advanced glycation end-products (sRAGE), pregnancy-associated plasma protein A (PAPP-A), E-selectin, vascular endothelial growth factor (VEGF) and B-type natriuretic peptide (BNP) levels were measured in serum of 21 CAD patients and in 22 healthy controls at rest and after exercise bicycle stress test performed up to the maximal tolerated effort. At rest, hs-CRP, AOPP, MMP-9 and BNP were significantly elevated in the CAD patients as compared with controls. In contrast, P-selectin was significantly lower in CAD patients and a tendency to lower levels of sRAGE was noted. After exercise MMP-9 and BNP, increased significantly in both groups. In conclusions, CAD patients have elevated hs-CRP, AOPP, MMP-9 and BNP--novel markers related to cardiovascular risk or left ventricular overload. MMP-9 and BNP increase significantly with exercise in both healthy individuals and CAD patients.
V Danzig; B Míková; P Kuchynka; H Benáková; T Zima; O Kittnar; J Skrha; A Linhart; M Kalousová
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-12
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  59     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-09-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  385-92     Citation Subset:  IM    
Second Department of Medicine, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic.
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MeSH Terms
Biological Markers / blood
Case-Control Studies
Coronary Artery Disease / blood*,  physiopathology*
Exercise Test
Exercise Tolerance
Inflammation Mediators / blood*
Middle Aged
Oxidative Stress*
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators

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