| Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients. | |
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MedLine Citation:
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PMID: 19681661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As traditional risk factors are unable to fully explain the pathogenesis of coronary artery disease (CAD), novel mechanisms became a target of many investigations. Our aim was to study the response of selected markers to physical exercise. High-sensitive C-reactive protein (hs-CRP), matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), advanced oxidation protein products (AOPP), soluble receptor for advanced glycation end-products (sRAGE), pregnancy-associated plasma protein A (PAPP-A), E-selectin, vascular endothelial growth factor (VEGF) and B-type natriuretic peptide (BNP) levels were measured in serum of 21 CAD patients and in 22 healthy controls at rest and after exercise bicycle stress test performed up to the maximal tolerated effort. At rest, hs-CRP, AOPP, MMP-9 and BNP were significantly elevated in the CAD patients as compared with controls. In contrast, P-selectin was significantly lower in CAD patients and a tendency to lower levels of sRAGE was noted. After exercise MMP-9 and BNP, increased significantly in both groups. In conclusions, CAD patients have elevated hs-CRP, AOPP, MMP-9 and BNP--novel markers related to cardiovascular risk or left ventricular overload. MMP-9 and BNP increase significantly with exercise in both healthy individuals and CAD patients. |
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Authors:
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V Danzig; B Míková; P Kuchynka; H Benáková; T Zima; O Kittnar; J Skrha; A Linhart; M Kalousová |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-12 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 59 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-29 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 385-92 Citation Subset: IM |
Affiliation:
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Second Department of Medicine, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bicycling Biological Markers / blood Case-Control Studies Coronary Artery Disease / blood*, physiopathology* Exercise* Exercise Test Exercise Tolerance Female Humans Inflammation Mediators / blood* Male Middle Aged Oxidative Stress* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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