Document Detail

Levels of bisphenol A in canned liquid infant formula products in Canada and dietary intake estimates.
MedLine Citation:
PMID:  18702469     Owner:  NLM     Status:  MEDLINE    
A sensitive, efficient, and reproducible method, based on solid phase extraction and derivatization with acetic anhydride followed by gas chromatography-mass spectrometry in selected-ion monitoring mode, was developed for the determination of bisphenol A (BPA) in liquid infant formula. The method quantification limit was 0.5 ng g(-1). Extraction recoveries were 85-94% over the concentration range of 2.5-20 ng g(-1). Good reproducibility of the method was observed at levels of 0.54 and 10.4 ng g(-1) with relative standard deviations of 5.0 and 2.8%, respectively. The method was used to analyze samples of 21 canned liquid infant formula products for BPA. BPA was detected in all samples at levels ranging from as low as 2.27 ng g(-1) to as high as 10.2 ng g(-1). The probable daily intakes of BPA due to consumption of canned liquid infant formula were estimated for infants from premature to 12-18 months of age. The maximum probable daily intake of BPA was 1.35 microg kg(-1) of body weight day(-1) for 0-1-month-old infants with the maximum formula intake, which is below the provisional tolerable daily intake for BPA established by Health Canada, 25 microg kg(-1) of body weight day(-1).
Xu-Liang Cao; Guy Dufresne; Stephane Belisle; Genevieve Clement; Mirka Falicki; Franca Beraldin; Anastase Rulibikiye
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Publication Detail:
Type:  Journal Article     Date:  2008-08-15
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7919-24     Citation Subset:  IM    
Food Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, 251 Frederick Banting Driveway, AL: 2203D, Ottawa, Ontario, Canada K1A 0L2.
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MeSH Terms
Food Contamination / analysis*
Gas Chromatography-Mass Spectrometry
Infant Formula / chemistry*
Infant, Newborn
Infant, Premature
Phenols / analysis*
Quality Control
Reproducibility of Results
Reg. No./Substance:
0/Phenols; 80-05-7/bisphenol A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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