Document Detail


Levels of biogenic amines, their metabolites, and tyrosine hydroxylase activity in the human epileptic temporal cortex.
MedLine Citation:
PMID:  1968684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels of serotonin (5-HT), 5 hydroxyindoleacetic acid (5-HIAA), dopamine (DA), homovanillic acid (HVA), norepinephrine (NE), and tyrosine hydroxylase (TH) activity were measured in the focus (spiking) and nonfocus (nonspiking) regions of the temporal neocortex of 20 patients with intractable complex partial seizures. The levels of 5-HT, DA, 5-HIAA, and HVA were higher in the focus when compared to the nonfocus. Values for NE and TH activity were not different when focus and nonfocus were compared. The ratios of metabolite to precursor for 5-HT and DA were not significantly different between the focus and the nonfocus, suggesting that the changes observed were the result of a modification in the synthesis and release of these amines. Such changes in the epileptic focus could be caused by altered transsynaptic regulatory processes, which occur as a result of neuronal loss, gliosis, or neuronal sprouting.
Authors:
M Pintor; I N Mefford; I Hutter; S L Pocotte; A R Wyler; N S Nadi
Related Documents :
102654 - Capillary column gas chromatography--mass spectrometry in studies on rheumatoid arthritis.
2055084 - Intravenous bolus of prednisolone decreases 15-hydroxyeicosatetraenoic acid formation i...
21112364 - The nutritive value of grasspea (lathyrus sativus) and allied species, their toxicity t...
4209434 - Orosomucoid content of pleural and peritoneal effusions.
7177844 - An approach to the total synthesis of sinefungin.
1788054 - Zinc uptake by proximal cells isolated from rabbit kidney: effects of cysteine and hist...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  5     ISSN:  0887-4476     ISO Abbreviation:  Synapse     Publication Date:  1990  
Date Detail:
Created Date:  1990-04-09     Completed Date:  1990-04-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  152-6     Citation Subset:  IM    
Affiliation:
Medical Neurology Branch, NINDS, NIH, Bethesda, Maryland 20892.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biogenic Monoamines / metabolism*
Child
Epilepsy / metabolism*,  physiopathology
Female
Humans
Male
Middle Aged
Temporal Lobe / metabolism*,  physiopathology
Tyrosine 3-Monooxygenase / metabolism*
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; EC 1.14.16.2/Tyrosine 3-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Influence of enterectomy on peripheral tissue glutamine efflux in critically ill patients.
Next Document:  Synaptic modulation of N-methyl-D-aspartate receptor mediated responses in hippocampus.