Document Detail

Levels of biogenic amines, their metabolites, and tyrosine hydroxylase activity in the human epileptic temporal cortex.
MedLine Citation:
PMID:  1968684     Owner:  NLM     Status:  MEDLINE    
The levels of serotonin (5-HT), 5 hydroxyindoleacetic acid (5-HIAA), dopamine (DA), homovanillic acid (HVA), norepinephrine (NE), and tyrosine hydroxylase (TH) activity were measured in the focus (spiking) and nonfocus (nonspiking) regions of the temporal neocortex of 20 patients with intractable complex partial seizures. The levels of 5-HT, DA, 5-HIAA, and HVA were higher in the focus when compared to the nonfocus. Values for NE and TH activity were not different when focus and nonfocus were compared. The ratios of metabolite to precursor for 5-HT and DA were not significantly different between the focus and the nonfocus, suggesting that the changes observed were the result of a modification in the synthesis and release of these amines. Such changes in the epileptic focus could be caused by altered transsynaptic regulatory processes, which occur as a result of neuronal loss, gliosis, or neuronal sprouting.
M Pintor; I N Mefford; I Hutter; S L Pocotte; A R Wyler; N S Nadi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  5     ISSN:  0887-4476     ISO Abbreviation:  Synapse     Publication Date:  1990  
Date Detail:
Created Date:  1990-04-09     Completed Date:  1990-04-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  152-6     Citation Subset:  IM    
Medical Neurology Branch, NINDS, NIH, Bethesda, Maryland 20892.
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MeSH Terms
Biogenic Monoamines / metabolism*
Epilepsy / metabolism*,  physiopathology
Middle Aged
Temporal Lobe / metabolism*,  physiopathology
Tyrosine 3-Monooxygenase / metabolism*
Reg. No./Substance:
0/Biogenic Monoamines; EC 3-Monooxygenase

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