Document Detail

Levels of antibodies against protein C and protein S in pregnancy and in preeclampsia.
MedLine Citation:
PMID:  19900037     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The clinical relevance of antibodies anti-protein C and anti-protein S in pregnancy remains controversial. We evaluate whether, in the absence of thrombophilic diseases, maternal plasma levels of antibodies (IgM and IgG) change during pregnancy and in preeclampsia (PE), with and without superimposed fetal growth restriction (FGR). METHODS: A retrospective cohort of 50 women with PE (n = 30) and PE + FGR (n = 20) and 70 controls [first trimester (n = 20); second trimester (n = 20); third trimester (n = 30)] were enrolled in the study. RESULTS: In healthy pregnant women, plasma levels of anti-protein C antibodies decreased from first to third trimester and were below the range of positivity. IgM anti-protein-C and anti-protein-S were significantly higher (P < 0.001) in both PE (23.88 +/- 10.65 MoM and 43.90 +/- 20.45 MoM, respectively) and PE + FGR group (15.95 +/- 12.62 MoM and 36.02 +/- 27.43 MoM, respectively) than in control group (2.23 +/- 3.23 MoM and 1.68 +/- 4.075 MoM, respectively), in the presence of unchanged levels of IgG isotype. CONCLUSIONS: In this study, we first found that the production of anti-protein C and anti-protein S antibodies decreases throughout healthy pregnancies, while they circulate in high levels in women with PE and PE/FGR.
Michela Torricelli; Laura Sabatini; Pasquale Florio; Valentina Scaccia; Chiara Voltolini; Giulia Biliotti; Maria De Bonis; Felice Petraglia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  22     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-10     Completed Date:  2009-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  993-9     Citation Subset:  IM    
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.
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MeSH Terms
Autoantibodies / blood*
Case-Control Studies
Cohort Studies
Fetal Growth Retardation / blood
Immunoglobulin G / immunology
Immunoglobulin M / immunology
Pre-Eclampsia / blood*
Pregnancy / blood*
Pregnancy Trimesters
Protein C / immunology*
Protein S / immunology*
Retrospective Studies
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Protein C; 0/Protein S

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