Document Detail


Levels of angiogenic factors in pregnancy and post-partum bleeding.
MedLine Citation:
PMID:  18792843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied if serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) in pregnancy could predict excess post-partum bleeding. In 392 normotensive singleton pregnancies, concentrations of sFlt-1 and PlGF in the first, second, and third trimester were compared between women with and without excess post-partum bleeding, defined as blood loss volume of at least 500 mL. Mean concentrations of sFlt-1 were consistently higher in all three trimesters among women who had excess post-partum bleeding compared to women without this, but significantly higher only in the second trimester. For PlGF, there were no significant differences between the groups. High concentrations of the anti-angiogenic factor sFlt-1 in maternal circulation during pregnancy may be associated with an increased risk of excess post-partum bleeding.
Authors:
Anne Eskild; Stig Jeansson; Pål A Jenum; Anne C Staff; Ravi Thadhani; Ananth Karumanchi; Lars J Vatten
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  87     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-13     Completed Date:  2008-11-03     Revised Date:  2009-11-25    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1081-3     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Akershus University Hospital and the Faculty of Medicine, University of Oslo, Norway. anne.eskild@medisin.uio.no
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Female
Humans
Postpartum Hemorrhage / blood*
Pregnancy / blood*
Pregnancy Proteins / blood*
Statistics, Nonparametric
Vascular Endothelial Growth Factor Receptor-1 / blood*
Chemical
Reg. No./Substance:
0/Pregnancy Proteins; 144589-93-5/placenta growth factor; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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