| Levels of angiogenic factors in pregnancy and post-partum bleeding. | |
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MedLine Citation:
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PMID: 18792843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have studied if serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) in pregnancy could predict excess post-partum bleeding. In 392 normotensive singleton pregnancies, concentrations of sFlt-1 and PlGF in the first, second, and third trimester were compared between women with and without excess post-partum bleeding, defined as blood loss volume of at least 500 mL. Mean concentrations of sFlt-1 were consistently higher in all three trimesters among women who had excess post-partum bleeding compared to women without this, but significantly higher only in the second trimester. For PlGF, there were no significant differences between the groups. High concentrations of the anti-angiogenic factor sFlt-1 in maternal circulation during pregnancy may be associated with an increased risk of excess post-partum bleeding. |
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Authors:
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Anne Eskild; Stig Jeansson; Pål A Jenum; Anne C Staff; Ravi Thadhani; Ananth Karumanchi; Lars J Vatten |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 87 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-13 Completed Date: 2008-11-03 Revised Date: 2009-11-25 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 1081-3 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Akershus University Hospital and the Faculty of Medicine, University of Oslo, Norway. anne.eskild@medisin.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Female Humans Postpartum Hemorrhage / blood* Pregnancy / blood* Pregnancy Proteins / blood* Statistics, Nonparametric Vascular Endothelial Growth Factor Receptor-1 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Pregnancy Proteins; 144589-93-5/placenta growth factor; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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